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  • 产品名称：ATCC27064带小棒链霉菌标准菌株菌种

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简单介绍：
ATCC27064带小棒链霉菌标准菌株菌种
详情介绍：
出品公司:ATCC
_菌_种名称:ATCC 27064, ATCC27064
_菌_种又名:[NRRL 3585]
_菌_株类型:Streptomyces clavuligerus，带小棒链霉_菌_
存储人:CE Higgens
分离来源:土壤，南美
产品目录号:27064
其他保藏库编号:AS 4.1611 =ATCC 27064 =BCRC 11518 =CBS 226.75 =DSM 40751 =KCTC 9095 =NBRC 13307
培养基:
ATCC Medium 196: Yeast malt extract agar 酵母麦芽汁琼脂ATCC Medium 1877: ISP Medium 1 ISP培养基1号
 
生长条件:30 ℃,  有氧
生物安_全等级:1
基因组序列号:ABJH00000000, CM000913, CM001015
基因组是否测序:是
模式_菌_株:是
应用:细胞提取物能够通过环化作用将苯乙酰-L-半胱氨酰-D-缬氨酸转变为苄青霉素
_菌_株特点:
ATCC 27064是Streptomyces clavuligerus，带小棒链霉_菌_。

Nucleotide (GenBank) : A38835 Sequence 2 from Patent WO9412654. Nucleotide (GenBank) : A39664 Sequence 1 from Patent WO9418326. Nucleotide (GenBank) : A42941 Sequence 2 from Patent WO9503416. Nucleotide (GenBank) : AJ000671 Streptomyces clavuligerus car and claR genes. Nucleotide (GenBank) : AJ001743 Streptomyces clavuligerus pcd, cmcT and pbp2 genes. Nucleotide (GenBank) : Z81324 S.clavuligerus ccaR and blp genes and open open reading frame. Nucleotide (GenBank) : AF038457 Streptomyces clavuligerus strain ATCC 27064 plasmid pSCL2 terminus. Nucleotide (GenBank) : L06213 Streptomyces clavuligerus clavaminate synthase 1 (cs1) gene, complete cds. Nucleotide (GenBank) : Z49111 Streptomyces clavuligerus arginine biosynthesis cluster (argCJBDRGH genes). Nucleotide (GenBank) : AJ238211 Streptomyces clavuligerus ORF1, encoding a protein involved in clavulanic acid biosynthesis.
 
参考文献:Luengo JM, et al. Cyclization of phenylacetyl-L-cysteinyl-D-valine to benzylpenicillin using cell-free extracts of Streptomyces clavuligerus. J. Antibiot. 39: 1144-1147, 1986. PubMed: 3759664 Baldwin JE, et al. Isolation and partial characterization of ACV synthetase from Cephalosporium acremonium and Streptomyces clavuligerus. Evidence for the presence of phosphopantothenate in ACV synthetase. J. Antibiot. 44: 241-248, 1991. PubMed: 2010361 Zhang J, Demain AL. Regulation of ACV synthetase activity in the beta-lactam biosynthetic pathway of carbon sources and their metabolites. Arch. Microbiol. 158: 364-369, 1992. Howarth TT, et al. Antibiotics. US Patent 4,525,352 dated Jun 25 1985 Perez-Llarena FJ, et al. A regulatory gene (ccaR) required for cephamycin and clavulanic acid production in Strptomyces clavuligerus: amplification results in overproduction of both beta-Lactam compounds. J. Bacteriol. 179: 2053-2059, 1997. PubMed: 9068654

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