产品详情
简单介绍:
3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) Antibody
详情介绍:
3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) Antibody is a Rabbit Polyclonal antibody for the detection of HMGCR. HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Research Articles on 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR)
Target | 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) |
Clonality | Polyclonal |
Reactivity | Human |
Tested Applications | ELISA, IHC |
Host | Rabbit |
Recommended dilutions | IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
Conjugation | Unconjugated |
Immunogen | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase |
Isotype | IgG |
Form | Liquid |
Purity | ≥ 95% (SDS-PAGE) |
Purification | Purified by immunogen affinity chromatography. |
Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
Validity | 12 months. |
UniProt Primary AC | P04035 (UniProt, ExPASy) |
UniProt Secondary AC | B7Z3Y9, Q8N190 |
UniProt Entry Name | HMDH_HUMAN |
Gene Symbol | HMGCR |
GeneID | 3156 |
OMIM | 142910 |
HGNC | 5006 |
KEGG | hsa:3156 |
Ensembl | ENSG00000113161 |
String | 9606.ENSP00000287936 |
Molecular Weight | Observed MW: 120 kDa |
Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
Concentration | 2 mg/ml |
Availability | Shipped within 5-12 working days. |
Note | This product is for research use only. |
相关信息

- 细胞培养玄学-MRC-5细胞 2025-01-07
- Ocean NanoTech定制的详细步骤 2021-10-31
- click chemistry tools数据结果比... 2021-10-31
- LaysanBio代理商相关文献资料2020 2021-10-31
- Abbiotec代理的产品得到重复验证2020 2021-10-31
- zyagen Laboratories代理的产品得到... 2021-06-20
- Toxin Technologies代理商相关文献资... 2021-03-14
- 热烈祝贺玉博生物正式代理biocolor公司试剂产品... 2021-03-14
- 热烈祝贺玉博生物正式代理cytognos公司试剂产品... 2021-03-14
- Gelest代理的产品得到重复验证2020 2021-03-14