产品名称：3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) Antibody

3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) Antibody is a Rabbit Polyclonal antibody for the detection of HMGCR.

HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Target	3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, IHC
Host	Rabbit
Recommended dilutions	IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	3-hydroxy-3-methylglutaryl-Coenzyme A reductase
Isotype	IgG
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by immunogen affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	P04035 (UniProt, ExPASy)
UniProt Secondary AC	B7Z3Y9, Q8N190
UniProt Entry Name	HMDH_HUMAN
Gene Symbol	HMGCR
GeneID	3156
OMIM	142910
HGNC	5006
KEGG	hsa:3156
Ensembl	ENSG00000113161
String	9606.ENSP00000287936
Molecular Weight	Observed MW: 120 kDa
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR)