产品名称：26S Proteasome Non-ATPase Regulatory Subunit 2 (PSMD2) Antibody

PSMD2 Antibody is a Rabbit Polyclonal against PSMD2. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants of this gene.

Target	26S Proteasome Non-ATPase Regulatory Subunit 2 (PSMD2)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fragment corresponding to 138-420 AA of human PSMD2.
Isotype	IgG
Form	Lyophilized
Purification	Purified by antigen affinity column chromatography.
Reconstitution	Reconstitute in 100 µl of sterile distilled H2O with 50% glycerol.
Storage	Store at -20 °C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q13200 (UniProt, ExPASy)
UniProt Entry Name	PSMD2_HUMAN
Gene Symbol	PSMD2
GeneID	5708
OMIM	606223
NCBI Accession	NP_001265637.1 NM_001278708.1 NP_001265638.1 NM_001278709.1 NP_002799.3 NM_002808.4
HGNC	9559
KEGG	hsa:5708
Ensembl	ENSG00000175166
String	9606.ENSP00000310129
Molecular Weight	Observed MW: 100 kDa
Buffer	Prior to lyophilization: 1% BSA and 0.02% NaN3.
Specificity	Predicted to react with Mouse and Rat PSMD2.
Concentration	Lyophilized form: Not applicable. After reconstitution: 1 mg/ml.
Availability	Shipped within 7-15 working days.
Note	This product is for research use only.

Research Articles on 26S Proteasome Non-ATPase Regulatory Subunit 2 (PSMD2)