产品名称：ANTXR1 (pY425) Antibody

ANTXR1 is a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. This protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes.

Target	ANTXR1 (pY425)
Clonality	Polyclonal
Target Modification	Tyr425
Modification	Phosphorylation
Reactivity	Human
Tested Applications	ELISA, DB
Host	Rabbit
Recommended dilutions	DB: 1/500. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y425 of human ANTXR1.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by two-step phosphospecific peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9H6X2 (UniProt, ExPASy)
UniProt Secondary AC	A8K7U8, J7K7G4, J7KF88, Q4ZFV6, Q53QD8, Q96P02, Q9NVP3
Molecular Weight	Calculated MW: 62.8 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse and Rat ANTXR1.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on ANTXR1 (pY425)