产品名称：Alkaline Phosphatase, Tissue-Nonspecific Isozyme (ALPL) Antibody

Alkaline Phosphatase, Tissue-Nonspecific Isozyme (ALPL) Antibody is a Rabbit Polyclonal antibody for the detection of ALPL.

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. ALPL (Alkaline phosphatase, tissue-nonspecific isozyme) is also named as AP-TNAP, TNSALP and belongs to the alkaline phosphatase family. It can exsit as a homodimer with the molecular weight of 140 kDa (PMID:18724009). ALPL was synthesized as a 66-kDa endo-b-N-acetylglucos-aminidase H (Endo H) -sensitive form, and processed to an 80-kDa mature form, which is anchored to the plasma membrane via glycosylphosphatidylinositol (GPI) (PMID:10839996).This antibody can bind the four mentioned alkaline phosphatases.

Target	Alkaline Phosphatase, Tissue-Nonspecific Isozyme (ALPL)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	alkaline phosphatase, liver/bone/kidney
Isotype	IgG
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by immunogen affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	P05186 (UniProt, ExPASy)
UniProt Entry Name	PPBT_HUMAN
Gene Symbol	ALPL
GeneID	249
OMIM	146300
HGNC	438
KEGG	hsa:249
Ensembl	ENSG00000162551
String	9606.ENSP00000363973
Molecular Weight	Observed MW: 45-60 kDa
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on Alkaline Phosphatase, Tissue-Nonspecific Isozyme (ALPL)