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  • 产品名称：Human Adiponectin/Acrp30/ADIPOQ protein (Recombinant) (C-His) (STJP001454)

  • 产品型号：STJP001454
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human Adiponectin/Acrp30/ADIPOQ protein (Recombinant) (C-His) (STJP001454)
详情介绍：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human Adiponectin/Acrp30/ADIPOQ-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Gene Symbol: ADIPOQ
Gene ID: 9370
Uniprot ID: ADIPO_HUMAN
Immunogen: Recombinant Human Adiponectin/Acrp30/ADIPOQ Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu19-Asn244) of human Adiponectin/Acrp30 (Accession #NP_001171271.1) fused with a 6×His tag at the C-te
Post Translational Modifications HMW complexes are more extensively glycosylated than smaller oligomers. Hydroxylation and glycosylation of the lysine residues within the collagen-like domain of adiponectin seem to be critically involved in regulating the formation and/or secretion of HMW complexes and consequently contribute to the insulin-sensitizing activity of adiponectin in hepatocytes. O-glycosylated. Not N-glycosylated. O-linked glycans on hydroxylysines consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups. Sialylated to varying degrees depending on tissue. Thr-22 appears to be the major site of sialylation. Higher sialylation found in SGBS adipocytes than in HEK fibroblasts. Sialylation is not required neither for heterodimerization nor for secretion. Not sialylated on the glycosylated hydroxylysines. Desialylated forms are rapidly cleared from the circulation. Succination of Cys-36 by the Krebs cycle intermediate fumarate, which leads to S-(2-succinyl)cysteine residues, inhibits polymerization and secretion of adiponectin. Adiponectin is a major target for succination in both adipocytes and adipose tissue of diabetic mammals. It was proposed that succination of proteins is a biomarker of mitochondrial stress and accumulation of Krebs cycle intermediates in adipose tissue in diabetes and that succination of adiponectin may contribute to the decrease in plasma adiponectin in diabetes.
Function Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.
Protein Name Adiponectin
30 Kda Adipocyte Complement-Related Protein
Adipocyte Complement-Related 30 Kda Protein
Acrp30
Adipocyte - C1q And Collagen Domain-Containing Protein
Adipose Most Abundant Gene Transcript 1 Protein
Apm-1
Gelatin-Binding Protein
Database Links Reactome: R-HSA-163680
Reactome: R-HSA-381340
Cellular Localisation Secreted
Alternative Protein Names Adiponectin protein
30 Kda Adipocyte Complement-Related Protein protein
Adipocyte Complement-Related 30 Kda Protein protein
Acrp30 protein
Adipocyte - C1q And Collagen Domain-Containing Protein protein
Adipose Most Abundant Gene Transcript 1 Protein protein
Apm-1 protein
Gelatin-Binding Protein protein
ADIPOQ protein
ACDC protein
ACRP30 protein
APM1 protein
GBP28 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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