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  • 产品名称：Anti-ABCD2 antibody (420-500) (STJ118473)

  • 产品型号：STJ118473
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ABCD2 antibody (420-500) (STJ118473)
详情介绍：
Host: Rabbit
Applications: WB/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ABCD2 (420-500) is suitable for use in Western Blot and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IF/ICC 1:50-1:100
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ABCD2
Gene ID: 225
Uniprot ID: ABCD2_HUMAN
Immunogen Region: 420-500
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 420-500 of human ABCD2 (NP_005155.1).
Immunogen Sequence: TARVYNMFWVFDEVKRGIYK RTAVIQESESHSKNGAKVEL PLSDTLAIKGKVIDVDHGII CENVPIITPAGEVVASRLNF K
Tissue Specificity Predominantly expressed in brain and heart.
Function ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen. Like ABCD1 seems to have fatty acyl-CoA thioesterase (ACOT) and ATPase activities, according to this model, VLCFA-CoA as free VLCFA is transpoted in an ATP-dependent manner into peroxisomes after the hydrolysis of VLCFA-CoA mediated by the ACOT activity of ABCD2 (Probable). Shows overlapping substrate specificities with ABCD1 toward saturated fatty acids (FA) and monounsaturated FA (MUFA) but has a distinct substrate preference for shorter VLCFA (C22:0) and polyunsaturated fatty acid (PUFA) such as C22:6-CoA and C24:6-CoA (in vitro). Thus, may play a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation.
Protein Name Atp-Binding Cassette Sub-Family D Member 2
Adrenoleukodystrophy-Like 1
Adrenoleukodystrophy-Related Protein
Haldr
Database Links Reactome: R-HSA-1369062
Reactome: R-HSA-9603798
Cellular Localisation Peroxisome Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Atp-Binding Cassette Sub-Family D Member 2 antibody
Anti-Adrenoleukodystrophy-Like 1 antibody
Anti-Adrenoleukodystrophy-Related Protein antibody
Anti-Haldr antibody
Anti-ABCD2 antibody
Anti-ALD1 antibody
Anti-ALDL1 antibody
Anti-ALDR antibody
Anti-ALDRP antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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