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  • 产品名称：Human APLP-1 protein (Recombinant) (C-His) (STJP001344)

  • 产品型号：STJP001344
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human APLP-1 protein (Recombinant) (C-His) (STJP001344)
详情介绍：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human APLP-1-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Gene Symbol: APLP1
Gene ID: 333
Uniprot ID: APLP1_HUMAN
Immunogen: Recombinant Human APLP-1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser39-Glu580) of human APLP1 (Accession #NP_005157.1) fused with a 6×His tag at the C-terminus.
Post Translational Modifications Proteolytically cleaved by caspases during neuronal apoptosis. Cleaved, in vitro, at Asp-620 by caspase-3. N- and O-glycosylated. O-glycosylation with core 1 or possibly core 8 glycans. Glycosylation on Ser-227 is the preferred site to Thr-228.
Function May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding. Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I. The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis.
Protein Name Amyloid Beta Precursor Like Protein 1
Amyloid Beta
A4 Precursor-Like Protein 1
Amyloid-Like Protein 1
Aplp
Aplp-1 Cleaved Into - C30
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
C30: Cytoplasm
C-Terminally Processed In The Golgi Complex
Alternative Protein Names Amyloid Beta Precursor Like Protein 1 protein
Amyloid Beta protein
A4 Precursor-Like Protein 1 protein
Amyloid-Like Protein 1 protein
Aplp protein
Aplp-1 Cleaved Into - C30 protein
APLP1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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