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  • 产品名称：Human BMPR-1B/ALK-6 protein (Recombinant) (C-hFc&His) (STJP001235)

  • 产品型号：STJP001235
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human BMPR-1B/ALK-6 protein (Recombinant) (C-hFc&His) (STJP001235)
详情介绍：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human BMPR-1B/ALK-6-C-hFc&His protein was developed from hek293 cells and has a target region of C-hFc&His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Human BMP2 at 4 Mu g/mL (100 Mu L/well) can bind Human BMPRIB with a linear range of 20-338 ng/mL.2. Measured by its ability to inhibit rhBMP-4-induced alkaline phosphatase production
Gene Symbol: BMPR1B
Gene ID: 658
Uniprot ID: BMR1B_HUMAN
Immunogen: Active Recombinant Human BMPR-1B/ALK-6 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Lys14-Arg126) of human BMPR-IB/ALK-6 (Accession #NP_001194.1) fused with a Fc, 6×His tag at the C-terminus.
Function On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction.
Protein Name Bone Morphogenetic Protein Receptor Type-1b
Bmp Type-1b Receptor
Bmpr-1b
Cd Antigen Cdw293
Database Links Reactome: R-HSA-201451
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Bone Morphogenetic Protein Receptor Type-1b protein
Bmp Type-1b Receptor protein
Bmpr-1b protein
Cd Antigen Cdw293 protein
BMPR1B protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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