Name: Human BMPR-2 protein (Recombinant) (C-hFc) (STJP001413)
Brand: ST john's laboratory
SKU: STJP001413

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简单介绍：

Human BMPR-2 protein (Recombinant) (C-hFc) (STJP001413)

详情介绍：

Host:	HEK293 cells
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human BMPR-2-C-hFc protein was developed from hek293 cells and has a target region of C-hFc. For use in research applications.

Formulation:	Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Immunoreactivity:	Measured by its binding ability in a functional ELISA. Immobilized Human BMP2 at 1 Mu g/mL (100 Mu L/well) can bind Human BMPR2 with a linear range of 19.5 ng/ml-1.46 Mu g/ml.

Gene Symbol:	BMPR2
Gene ID:	659
Uniprot ID:	BMPR2_HUMAN
Immunogen:	Recombinant Human BMPR-2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser27-Ile151) of human BMPR2 (Accession #NP_001195.2) fused with a hFc tag at the C-terminus.

Function	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6.
Protein Name	Bone Morphogenetic Protein Receptor Type-2 Bmp Type-2 Receptor Bmpr-2 Bone Morphogenetic Protein Receptor Type Ii Bmp Type Ii Receptor Bmpr-Ii
Database Links	Reactome: R-HSA-201451
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein
Alternative Protein Names	Bone Morphogenetic Protein Receptor Type-2 protein Bmp Type-2 Receptor protein Bmpr-2 protein Bone Morphogenetic Protein Receptor Type Ii protein Bmp Type Ii Receptor protein Bmpr-Ii protein BMPR2 protein PPH1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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产品名称：Human BMPR-2 protein (Recombinant) (C-hFc) (STJP001413)