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  • 产品名称：Human Cathepsin D protein (Recombinant) (C-His) (STJP000985)

  • 产品型号：STJP000985
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human Cathepsin D protein (Recombinant) (C-His) (STJP000985)
详情介绍：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human Cathepsin D-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Immunoreactivity: Measured by its ability to cleave the fluorogenic peptide substrate, Mca-PLGL-Dpa-AR-NH2. The specific activity is >747 pmol/min/Mu g.
Gene Symbol: CTSD
Gene ID: 1509
Uniprot ID: CATD_HUMAN
Immunogen Region: Leu21-Leu412
Immunogen: Recombinant Human Cathepsin D Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Leu21-Leu412) of human Cathepsin D/CTSD (Accession #NP_001900.1) fused with a 6×His tag at the C-terminus.
Tissue Specificity Expressed in the aorta extracellular space (at protein level). Expressed in liver (at protein level).
Post Translational Modifications N- and O-glycosylated. Undergoes proteolytic cleavage and activation by ADAM30. As well as the major heavy chain which starts at Leu-169, 2 minor forms starting at Gly-170 and Gly-171 have been identified. An additional form starting at Ala-168 has also been identified.
Function Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.
Protein Name Cathepsin D Cleaved Into - Cathepsin D Light Chain - Cathepsin D Heavy Chain
Database Links Reactome: R-HSA-1442490
Reactome: R-HSA-2022377
Reactome: R-HSA-2132295
Reactome: R-HSA-6798695
Reactome: R-HSA-77387
Reactome: R-HSA-9018519
Cellular Localisation Lysosome
Melanosome
Secreted
Extracellular Space
Identified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv
In Aortic Samples
Detected As An Extracellular Protein Loosely Bound To The Matrix
Alternative Protein Names Cathepsin D Cleaved Into - Cathepsin D Light Chain - Cathepsin D Heavy Chain protein
CTSD protein
CPSD protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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