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  • 产品名称：Anti-ACD antibody (1-220) (STJ114070)

  • 产品型号：STJ114070
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ACD antibody (1-220) (STJ114070)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ACD (1-220) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ACD
Gene ID: 65057
Uniprot ID: ACD_HUMAN
Immunogen Region: 1-220
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ACD (NP_001075955.1).
Immunogen Sequence: MPGRCQSDAAMRVNGPASRA PAGWTSGSLHTGPRAGRPRA QARGVRGRGLLLRPRPAKEL PLPRKGGAWAPAGNPGPLHP LGVAVGMAGSGRLVLRPWIR ELILGSETPSSPRAGQLLEV LQDAEAAVAGPSHAPDTSDV GATLLVSDGTHSVRCLVTRE ALDTSDWEEKEFGFRGTEGR LLLLQDCGVHVQVAEGGAPA EFYLQVDRFSLLPTEQPRLR
Function Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.
Protein Name Adrenocortical Dysplasia Protein Homolog
Pot1 And Tin2-Interacting Protein
Database Links Reactome: R-HSA-110328
Reactome: R-HSA-110329
Reactome: R-HSA-110330
Reactome: R-HSA-110331
Reactome: R-HSA-1221632
Reactome: R-HSA-171306
Reactome: R-HSA-171319
Reactome: R-HSA-174411
Reactome: R-HSA-174414
Reactome: R-HSA-174417
Reactome: R-HSA-174430
Reactome: R-HSA-174437
Reactome: R-HSA-2559586
Reactome: R-HSA-9670095
Cellular Localisation Nucleus
Chromosome
Telomere
Alternative Antibody Names Anti-Adrenocortical Dysplasia Protein Homolog antibody
Anti-Pot1 And Tin2-Interacting Protein antibody
Anti-ACD antibody
Anti-PIP1 antibody
Anti-PTOP antibody
Anti-TINT1 antibody
Anti-TPP1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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