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  • 产品名称：Anti-ACER2 antibody (50-130 aa) (STJ97626)

  • 产品型号：STJ97626
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ACER2 antibody (50-130 aa) (STJ97626)
详情介绍：
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Monkey
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Alkaline ceramidase 2 (50-130 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC-P 1:100-1:300
ELISA 1:10000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ACER2
Gene ID: 340485
Uniprot ID: ACER2_HUMAN
Immunogen Region: 50-130 aa
Specificity: ASAH3L Polyclonal Antibody detects endogenous levels of ASAH3L protein.
Immunogen: Synthesized peptide derived from ASAH3L at the amino acid range 50-130
Function Golgi ceramidase that catalyzes the hydrolysis of ceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Has a better catalytic efficiency towards unsaturated long-chain ceramides, including C18:1-, C20:1- and C24:1-ceramides. Saturated long-chain ceramides and unsaturated very long-chain ceramides are also good substrates, whereas saturated very long-chain ceramides and short-chain ceramides are poor substrates. Also hydrolyzes dihydroceramides to produce dihydrosphingosine. It is the ceramidase that controls the levels of circulating sphingosine-1-phosphate and dihydrosphingosine-1-phosphate in plasma through their production by hematopoietic cells. Regulates cell proliferation, autophagy and apoptosis by the production of sphingosine and sphingosine-1-phosphate. As part of a p53/TP53-dependent pathway, promotes for instance autophagy and apoptosis in response to DNA damage. Through the production of sphingosine, may also regulate the function of the Golgi complex and regulate the glycosylation of proteins.
Protein Name Alkaline Ceramidase 2
Alkcdase 2
Alkaline Cdase 2
Hacer2
Acylsphingosine Deacylase 3-Like
N-Acylsphingosine Amidohydrolase 3-Like
Database Links Reactome: R-HSA-1660661
Cellular Localisation Golgi Apparatus Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Alkaline Ceramidase 2 antibody
Anti-Alkcdase 2 antibody
Anti-Alkaline Cdase 2 antibody
Anti-Hacer2 antibody
Anti-Acylsphingosine Deacylase 3-Like antibody
Anti-N-Acylsphingosine Amidohydrolase 3-Like antibody
Anti-ACER2 antibody
Anti-ASAH3L antibody
Anti-PP11646 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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