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  • 产品名称：Anti-ABCA2 antibody (Internal) (STJ71599)

  • 产品型号：STJ71599-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ABCA2 antibody (Internal) (STJ71599)
详情介绍：
Host: Goat
Applications: Pep-ELISA/IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-ABCA2 (Internal) is suitable for use in ELISA and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: IHC-3.75µg/ml
ELISA-antibody detection limit dilution 1:2000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: ABCA2
Gene ID: 20
Uniprot ID: ABCA2_HUMAN
Immunogen Region: Internal
Accession Number: NP_001597.2; NP_997698.1
Specificity: This antibody is expected to recognize both reported isoforms (NP_001597.2; NP_997698.1).
Immunogen Sequence: KKQSDNLEQQETEP
Post Translational Modifications Methylated at Gln-271 by N6AMT1.
Function Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (Probable). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes. In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP. May play a role in myelin formation.
Protein Name Atp-Binding Cassette Sub-Family A Member 2
Atp-Binding Cassette Transporter 2
Atp-Binding Cassette 2
Database Links Reactome: R-HSA-1369062
Cellular Localisation Endosome Membrane
Multi-Pass Membrane Protein
Lysosome Membrane
Forms Discrete
Punctate Intracellular Vesicles
Alternative Antibody Names Anti-Atp-Binding Cassette Sub-Family A Member 2 antibody
Anti-Atp-Binding Cassette Transporter 2 antibody
Anti-Atp-Binding Cassette 2 antibody
Anti-ABCA2 antibody
Anti-ABC2 antibody
Anti-KIAA1062 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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