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  • 产品名称：ASF1A Blocking Peptide for STJ500173 peptide (STJ503686)

  • 产品型号：STJ503686-250
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
ASF1A Blocking Peptide for STJ500173 peptide (STJ503686)
详情介绍：
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: ASF1A Blocking Peptide for STJ500173 is synthetically produced from the 60-120 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: ASF1A
Gene ID: 25842
Uniprot ID: ASF1A_HUMAN
Immunogen Region: 60-120
Specificity: This blocking peptide is recommended for use in combination with ASF1A antibody, STJ500173
Immunogen: Synthetic peptide taken within amino acid region 60-120 on human AF1A protein.
Tissue Specificity Ubiquitously expressed.
Post Translational Modifications Phosphorylated by TLK1 and TLK2. Highly phosphorylated in S-phase and at lower levels in M-phase. TLK2-mediated phosphorylation at Ser-192 prevents proteasome-dependent degradation. Phosphorylation at Ser-192 by PRKDC in response to DNA damage promotes the histone chaperone activity and ability to replace histones at double-strand breaks (DSBs) at stalled or collapsed replication forks, leading to RAD51 recruitment.
Function Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks: acts by mediating histone replacement at DSBs, leading to recruitment of the MMS22L-TONSL complex and subsequent loading of RAD51. Also involved in the nuclear import of the histone H3-H4 dimer together with importin-4 (IPO4): specifically recognizes and binds newly synthesized histones with the monomethylation of H3 'Lys-9' and acetylation at 'Lys-14' (H3K9me1K14ac) marks, and diacetylation at 'Lys-5' and 'Lys-12' of H4 (H4K5K12ac) marks in the cytosol. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.
Peptide Name Histone Chaperone Asf1a
Anti-Silencing Function Protein 1 Homolog A
Hasf1
Hasf1a
Ccg1-Interacting Factor A
Cia
Hcia
Database Links Reactome: R-HSA-2559584
Cellular Localisation Nucleus
Chromosome
Alternative Peptide Names Histone Chaperone Asf1a protein
Anti-Silencing Function Protein 1 Homolog A protein
Hasf1 protein
Hasf1a protein
Ccg1-Interacting Factor A protein
Cia protein
Hcia protein
ASF1A protein
CGI-98 protein
HSPC146 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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