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  • 产品名称：BMP1 Blocking Peptide for STJ500268 peptide (STJ503726)

  • 产品型号：STJ503726-250
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
BMP1 Blocking Peptide for STJ500268 peptide (STJ503726)
详情介绍：
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: BMP1 Blocking Peptide for STJ500268 is synthetically produced from the 680-730 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: BMP1
Gene ID: 649
Uniprot ID: BMP1_HUMAN
Immunogen Region: 680-730
Specificity: This blocking peptide is recommended for use in combination with BMP1 antibody, STJ500268
Immunogen: Synthetic peptide taken within amino acid region 680-730 on human BMP1 protein.
Tissue Specificity Ubiquitous.
Post Translational Modifications Proteolytically activated in the trans-Golgi network by furin-like/paired basic proprotein convertases, cleavage is not required for secretion.
Function Metalloprotease that plays key roles in regulating the formation of the extracellular matrix (ECM) via processing of various precursor proteins into mature functional enzymes or structural proteins. Thereby participates in several developmental and physiological processes such as cartilage and bone formation, muscle growth and homeostasis, wound healing and tissue repair. Roles in ECM formation include cleavage of the C-terminal propeptides from procollagens such as procollagen I, II and III or the proteolytic activation of the enzyme lysyl oxidase LOX, necessary to formation of covalent cross-links in collagen and elastic fibers. Additional substrates include matricellular thrombospondin-1/THBS1 whose cleavage leads to cell adhesion disruption and TGF-beta activation. Isoform BMP1-3: Plays an important role in bone repair by acting as a coactivator of BMP7.
Peptide Name Bone Morphogenetic Protein 1
Bmp-1
Mammalian Tolloid Protein
Mtld
Procollagen C-Proteinase
Pcp
Database Links Reactome: R-HSA-1474228
Reactome: R-HSA-1650814
Reactome: R-HSA-2214320
Reactome: R-HSA-2243919
Reactome: R-HSA-8963896 P13497-3
Cellular Localisation Golgi Apparatus
Trans-Golgi Network
Secreted
Extracellular Space
Extracellular Matrix
Co-Localizes With Postn In The Golgi
Isoform Bmp1-3: Secreted
Alternative Peptide Names Bone Morphogenetic Protein 1 protein
Bmp-1 protein
Mammalian Tolloid Protein protein
Mtld protein
Procollagen C-Proteinase protein
Pcp protein
BMP1 protein
PCOLC protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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