产品详情
查看大图

  • 产品名称：Human CD177 protein (Recombinant) (C-hFc&His) (STJP001213)

  • 产品型号：STJP001213
  • 产品厂商：ST john's laboratory
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
Human CD177 protein (Recombinant) (C-hFc&His) (STJP001213)
详情介绍：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human CD177-C-hFc&His protein was developed from hek293 cells and has a target region of C-hFc&His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Gene Symbol: CD177
Gene ID: 57126
Uniprot ID: CD177_HUMAN
Immunogen Region: Met1-Gly407
Immunogen: Recombinant Human CD177 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Gly407) of human CD177 (Accession #NP_065139.2.) fused with a Fc, 6×His tag at the C-terminus.
Tissue Specificity Highly expressed in normal bone marrow and weakly expressed in fetal liver. During neutrophil differentiation, expression begins at the metamyelocyte stage and continues throughout the subsequent stages (at protein level). Expressed by a subset of mature neutrophils (at protein level). The percentage of neutrophils expressing CD177 varies across the population. Expressed in granulocytes of patients with polycythemia vera (PV) and with essential thrombocythemia (ET).
Post Translational Modifications N-glycosylated. A soluble form may also be produced by proteolytic cleavage at the cell surface (shedding).
Function In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18, mediates activation of TNF-alpha primed neutrophils including degranulation and superoxide production. In addition, by preventing beta-2 integrin internalization and attenuating chemokine signaling favors adhesion over migration. Heterophilic interaction with PECAM1 on endothelial cells plays a role in neutrophil transendothelial migration in vitro. However, appears to be dispensable for neutrophil recruitment caused by bacterial infection in vivo. Acts as a receptor for the mature form of protease PRTN3 allowing its display at the cell surface of neutrophils. By displaying PRTN3 at the neutrophil cell surface, may play a role in enhancing endothelial cell junctional integrity and thus vascular integrity during neutrophil diapedesis.
Protein Name Cd177 Antigen
Human Neutrophil Alloantigen 2a
Hna-2a
Nb1 Glycoprotein
Nb1 Gp
Polycythemia Rubra Vera Protein 1
Prv-1
Cd Antigen Cd177
Database Links Reactome: R-HSA-140875
Reactome: R-HSA-202733
Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Membrane Raft
Gpi-Like-Anchor
Secreted
Cytoplasmic Granule Membrane
Cell Projection
Lamellipodium
Cell Surface Expression On Neutrophils Is Increased Upon Tnf-Alpha
Fmlp Or Cxcl8/Il8-Mediated Stimulation
In Neutrophils
Stored Predominantly In Secondary And Tertiary Granules
Can Also Be Shedded From The Cell Membrane
Localizes To Lamellar Protrusions In Spreading Neutrophils
Alternative Protein Names Cd177 Antigen protein
Human Neutrophil Alloantigen 2a protein
Hna-2a protein
Nb1 Glycoprotein
Nb1 Gp protein
Polycythemia Rubra Vera Protein 1 protein
Prv-1 protein
Cd Antigen Cd177 protein
CD177 protein
NB1 protein
PRV1 protein
UNQ595 protein
PRO1181 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
姓名：
电话：
您的需求：
 

沪公网安备 31011002002624号