产品详情
查看大图

  • 产品名称：Human CD6 protein (Recombinant) (C-hFc&His) (STJP001160)

  • 产品型号：STJP001160
  • 产品厂商：ST john's laboratory
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
Human CD6 protein (Recombinant) (C-hFc&His) (STJP001160)
详情介绍：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human CD6-C-hFc&His protein was developed from hek293 cells and has a target region of C-hFc&His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Human CD166 at 1 Mu g/mL (100 Mu L/well) can bind Human CD6 with a linear range of 4-389 ng/mL.2. Measured by the ability of the immobilized protein to support the adhesion of Jurkat
Gene Symbol: CD6
Gene ID: 923
Uniprot ID: CD6_HUMAN
Immunogen Region: His18-Glu398
Immunogen: Recombinant Human CD6 Protein is produced by HEK293cells expression system. The target protein is expressed with sequence (His18-Glu398) of human CD6 (Accession #NP_006716.3) fused with an Fc, 6×His tag at the C-terminus.
Tissue Specificity Detected on thymocytes. Detected on peripheral blood T-cells. Detected on natural killer (NK) cells. Soluble CD6 is detected in blood serum (at protein level). Detected in spleen, thymus, appendix, lymph node and peripheral blood leukocytes. Expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain.
Post Translational Modifications After T-cell activation, becomes hyperphosphorylated on Ser and Thr residues and phosphorylated on Tyr residues. Glycosylated.
Function Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166. Contributes to signaling cascades triggered by activation of the TCR/CD3 complex. Functions as costimulatory molecule.promotes T-cell activation and proliferation. Contributes to the formation and maturation of the immunological synapse. Functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria. LPS binding leads to the activation of signaling cascades and down-stream MAP kinases. Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS.
Protein Name T-Cell Differentiation Antigen Cd6
T12
Tp120
Cd Antigen Cd6 Cleaved Into - Soluble Cd6
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Detected At The Immunological Synapse
I
E
At The Contact Zone Between Antigen-Presenting Dendritic Cells And T-Cells
Colocalizes With The Tcr/Cd3 Complex At The Immunological Synapse
Soluble Cd6: Secreted
The Origins Of The Secreted Form Are Not Clear
But It Might Be Created By Proteolytic Shedding Of The Ectodomain
Alternative Protein Names T-Cell Differentiation Antigen Cd6 protein
T12 protein
Tp120 protein
Cd Antigen Cd6 Cleaved Into - Soluble Cd6 protein
CD6 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
姓名：
电话：
您的需求：
 

沪公网安备 31011002002624号