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  • 产品名称：Anti-Acetyl-NCOA3-Lys616 antibody (STJA0005992)

  • 产品型号：STJA0005992
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-Acetyl-NCOA3-Lys616 antibody (STJA0005992)
详情介绍：
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Acetyl-Nuclear receptor coactivator 3-Lys616 is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:1000-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: NCOA3
Gene ID: 8202
Uniprot ID: NCOA3_HUMAN
Specificity: This antibody detects endogenous levels of Human NCoA-3 (Acetyl Lys616)
Immunogen: Synthesized peptide derived from human NCoA-3 (Acetyl Lys616)
Tissue Specificity Widely expressed. High expression in heart, skeletal muscle, pancreas and placenta. Low expression in brain, and very low in lung, liver and kidney.
Post Translational Modifications Acetylated by CREBBP. Acetylation occurs in the RID domain, and disrupts the interaction with nuclear receptors and regulates its function. Methylated by CARM1. Phosphorylated by IKK complex. Regulated its function. Phosphorylation at Ser-601 by CK1 promotes coactivator function.
Function Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.
Protein Name Nuclear Receptor Coactivator 3
Ncoa-3
Actr
Amplified In Breast Cancer 1 Protein
Aib-1
Cbp-Interacting Protein
Pcip
Class E Basic Helix-Loop-Helix Protein 42
Bhlhe42
Receptor-Associated Coactivator 3
Rac-3
Steroid Receptor Coactivator Protein 3
Src-3
Thyroid Hormone Receptor Activator Molecule 1
Tram-1
Database Links Reactome: R-HSA-1989781
Reactome: R-HSA-381340
Reactome: R-HSA-5617472
Reactome: R-HSA-5687128
Reactome: R-HSA-9018519
Cellular Localisation Cytoplasm
Nucleus
Mainly Cytoplasmic And Weakly Nuclear
Upon Tnf Activation And Subsequent Phosphorylation
It Translocates From The Cytoplasm To The Nucleus
Alternative Antibody Names Anti-Nuclear Receptor Coactivator 3 antibody
Anti-Ncoa-3 antibody
Anti-Actr antibody
Anti-Amplified In Breast Cancer 1 Protein antibody
Anti-Aib-1 antibody
Anti-Cbp-Interacting Protein antibody
Anti-Pcip antibody
Anti-Class E Basic Helix-Loop-Helix Protein 42 antibody
Anti-Bhlhe42 antibody
Anti-Receptor-Associated Coactivator 3 antibody
Anti-Rac-3 antibody
Anti-Steroid Receptor Coactivator Protein 3 antibody
Anti-Src-3 antibody
Anti-Thyroid Hormone Receptor Activator Molecule 1 antibody
Anti-Tram-1 antibody
Anti-NCOA3 antibody
Anti-AIB1 antibody
Anti-BHLHE42 antibody
Anti-RAC3 antibody
Anti-TRAM1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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