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  • 产品名称：Anti-Acetyl-SP3-Lys551 antibody (STJA0005991)

  • 产品型号：STJA0005991
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-Acetyl-SP3-Lys551 antibody (STJA0005991)
详情介绍：
Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Acetyl-Transcription factor Sp3-Lys551 is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
IHC-p 1:50-300
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SP3
Gene ID: 6670
Uniprot ID: SP3_HUMAN
Specificity: This antibody detects endogenous levels of Human, Mouse Sp3 (Acetyl Lys551)
Immunogen: Synthesized peptide derived from human Sp3 (Acetyl Lys551)
Tissue Specificity Ubiquitously expressed.
Post Translational Modifications Not glycosylated. Acetylated by histone acetyltransferase p300, deacetylated by HDACs. Acetylation/deacetylation states regulate transcriptional activity. Acetylation appears to activate transcription. Alternate sumoylation and acetylation at Lys-551 also control transcriptional activity. Ceramides can also regulate acetylation/deacetylation events through altering the interaction of HDAC with SP3. In vitro, C(18)-ceramides, but not C(16)-ceramides, increase the interaction of HDAC1 with SP3 and enhance the deacetylation of SP3 and the subsequent repression of the TERT promoter. Sumoylated on all isoforms. Sumoylated on 2 sites in longer isoforms with Lys-551 being the major site. Sumoylation at this site promotes nuclear localization to the nuclear periphery, nuclear dots and PML nuclear bodies. Sumoylation on Lys-551 represses the transactivation activity, except for the largest isoform, L-Sp3, which has little effect on transactivation. Alternate sumoylation and acetylation at Lys-551 also control transcriptional activity.
Function Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping.
Protein Name Transcription Factor Sp3
Spr-2
Database Links Reactome: R-HSA-3232118
Cellular Localisation Nucleus
Pml Body
Localizes To The Nuclear Periphery And In Nuclear Dots When Sumoylated
Some Localization In Pml Nuclear Bodies
Alternative Antibody Names Anti-Transcription Factor Sp3 antibody
Anti-Spr-2 antibody
Anti-SP3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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