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  • 产品名称：CRMP2 Blocking Peptide peptide (STJ503872)

  • 产品型号：STJ503872-250
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
CRMP2 Blocking Peptide peptide (STJ503872)
详情介绍：
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: CRMP2 Blocking Peptide is synthetically produced from the 60-115 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: DPYSL2
Gene ID: 1808
Uniprot ID: DPYL2_HUMAN
Immunogen Region: 60-115
Immunogen: Synthetic peptide taken from within the region corresponding to AA 60-115 of the CRMP2 protein. The 26mer peptide was conserved in several other species. The selected peptide was post-synthetically modified to achieve highest antigenicity before coup
Tissue Specificity Ubiquitous.
Post Translational Modifications 3F4, a monoclonal antibody which strongly stains neurofibrillary tangles in Alzheimer disease brains, specifically labels DPYSL2 when phosphorylated on Ser-518, Ser-522 and Thr-509. Phosphorylation at Thr-514 by GSK3B abolishes tubulin-binding leading to destabilization of microtubule assembly in axons and neurodegeneration. Phosphorylation by DYRK2 at Ser-522 is required for subsequent phosphorylation by GSK3B.
Function Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.
Peptide Name Dihydropyrimidinase-Related Protein 2
Drp-2
Collapsin Response Mediator Protein 2
Crmp-2
N2a3
Unc-33-Like Phosphoprotein 2
Ulip-2
Database Links Reactome: R-HSA-399956
Reactome: R-HSA-437239
Cellular Localisation Cytoplasm
Cytosol
Cytoskeleton
Membrane
Tightly But Non-Covalently Associated With Membranes
Alternative Peptide Names Dihydropyrimidinase-Related Protein 2 protein
Drp-2 protein
Collapsin Response Mediator Protein 2 protein
Crmp-2 protein
N2a3 protein
Unc-33-Like Phosphoprotein 2 protein
Ulip-2 protein
DPYSL2 protein
CRMP2 protein
ULIP2 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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