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  • 产品名称：Human CX3CL1/Fractalkine protein (Recombinant) (C-hFc) (STJP001904)

  • 产品型号：STJP001904
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human CX3CL1/Fractalkine protein (Recombinant) (C-hFc) (STJP001904)
详情介绍：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human CX3CL1/Fractalkine-C-hFc protein was developed from hek293 cells and has a target region of C-hFc. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CX3CL1
Gene ID: 6376
Uniprot ID: X3CL1_HUMAN
Immunogen Region: Gln25-Gly100
Immunogen: Recombinant Human CX3CL1/Fractalkine Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln25-Gly100) of human CX3CL1/Fractalkine (Accession #) fused with and a HuFc tag at the C-terminus.
Post Translational Modifications A soluble short 95 kDa form may be released by proteolytic cleavage from the long membrane-anchored form. O-glycosylated with core 1 or possibly core 8 glycans.
Function Chemokine that acts as a ligand for both CX3CR1 and integrins ITGAV:ITGB3 and ITGA4:ITGB1. The CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis. Regulates leukocyte adhesion and migration processes at the endothelium. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1. Processed fractalkine: The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. Fractalkine: The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. (Microbial infection) Mediates the cytoadherence of erythrocytes infected with parasite P.falciparum (strain 3D7) with endothelial cells by interacting with P.falciparum CBP1 and CBP2 expressed at the surface of erythrocytes. The adhesion prevents the elimination of infected erythrocytes by the spleen (Probable).
Protein Name Fractalkine
C-X3-C Motif Chemokine 1
Cx3c Membrane-Anchored Chemokine
Neurotactin
Small-Inducible Cytokine D1 Cleaved Into - Processed Fractalkine
Database Links Reactome: R-HSA-380108
Reactome: R-HSA-418594
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Processed Fractalkine: Secreted
Alternative Protein Names Fractalkine protein
C-X3-C Motif Chemokine 1 protein
Cx3c Membrane-Anchored Chemokine protein
Neurotactin protein
Small-Inducible Cytokine D1 Cleaved Into - Processed Fractalkine protein
CX3CL1 protein
FKN protein
NTT protein
SCYD1 protein
A-152E5.2 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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