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  • 产品名称：Anti-ACPP antibody (40-300) (STJ115418)

  • 产品型号：STJ115418
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ACPP antibody (40-300) (STJ115418)
详情介绍：
Host: Rabbit
Applications: IHC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ACPP (40-300) is suitable for use in Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: IHC-P 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ACP3
Gene ID: 55
Uniprot ID: PPAP_HUMAN
Immunogen Region: 40-300
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 40-300 of human Prostatic Acid Phosphatase (PAP/Prostatic Acid Phosphatase (ACPP) ) (NP_001090.2).
Immunogen Sequence: LVFRHGDRSPIDTFPTDPIK ESSWPQGFGQLTQLGMEQHY ELGEYIRKRYRKFLNESYKH EQVYIRSTDVDRTLMSAMTN LAALFPPEGVSIWNPILLWQ PIPVHTVPLSEDQLLYLPFR NCPRFQELESETLKSEEFQK RLHPYKDFIATLGKLSGLHG QDLFGIWSKVYDPLYCESVH NFTLPSWATEDTMTKLRELS ELSLLSLYGIHKQKEKSRLQ GGVLVNEILNHMKRATQIP
Tissue Specificity Highly expressed in the prostate, restricted to glandular and ductal epithelial cells. Also expressed in bladder, kidney, pancreas, lung, cervix, testis and ovary. Weak expression in a subset of pancreatic islet cells, squamous epithelia, the pilosebaceous unit, colonic neuroendocrine cells and skin adnexal structures. Low expression in prostate carcinoma cells and tissues. Isoform 2: Widely expressed. Expressed in the sarcolemma of skeletal muscle.
Post Translational Modifications N-glycosylated. High mannose content, partially sialylated and fucosylated biantennary complex. Also fucosylated with partially sialylated triantennary complex oligosaccharides. Proteolytically cleaved in seminal fluid to produce several peptides. Peptide PAPf39, the most prominent, forms amyloid beta-sheet fibrils, SEVI (semen-derived enhancer of viral infection).
Function A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma. Isoform 2: Tyrosine phosphatase that acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling. In addition to its tyrosine phosphatase activity has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. PAPf39: (Microbial infection) Forms amyloid beta-sheet fibrils in semen. These fibrils, termed SEVI (semen-derived enhancer of viral infection) capture HIV virions, attach them to target cells and enhance infection. SEVI amyloid fibrils are degraded by polyphenol epigallocatechin-3-gallate (EGCG), a constituent of green tea. Target cell attachment and enhancement of HIV infection is inhibited by surfen. Also similarly boosts XMRV (xenotropic murine leukemia virus-related virus) infection.
Protein Name Prostatic Acid Phosphatase
Pap
5'-Nucleotidase
5'-Nt
Acid Phosphatase 3
Ecto-5'-Nucleotidase
Protein Tyrosine Phosphatase Acp3
Thiamine Monophosphatase
Tmpase Cleaved Into - Papf39
Database Links Reactome: R-HSA-6798695
Cellular Localisation Isoform 1: Secreted
Isoform 2: Cell Membrane
Single-Pass Type I Membrane Protein
Lysosome Membrane
Nucleus
Cytoplasm
Cytosol
Appears To Shuttle Between The Cell Membrane And Intracellular Vesicles
Colocalizes With Flot1 At Cell Membrane And In Intracellular Vesicles
Colocalizes With Lamp2 On The Lysosome Membrane
Alternative Antibody Names Anti-Prostatic Acid Phosphatase antibody
Anti-Pap antibody
Anti-5'-Nucleotidase antibody
Anti-5'-Nt antibody
Anti-Acid Phosphatase 3 antibody
Anti-Ecto-5'-Nucleotidase antibody
Anti-Protein Tyrosine Phosphatase Acp3 antibody
Anti-Thiamine Monophosphatase antibody
Anti-Tmpase Cleaved Into - Papf39 antibody
Anti-ACP3 antibody
Anti-ACPP antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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