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  • 产品名称：Human CXCL12/SDF-1 protein (Recombinant) (C-RaFC) (STJP001839)

  • 产品型号：STJP001839
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human CXCL12/SDF-1 protein (Recombinant) (C-RaFC) (STJP001839)
详情介绍：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human CXCL12/SDF-1-C-RaFC protein was developed from hek293 cells and has a target region of C-RaFC. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CXCL12
Gene ID: 6387
Uniprot ID: SDF1_HUMAN
Immunogen Region: Lys22-Met93
Immunogen: Recombinant Human CXCL12/SDF-1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Lys22-Met93) of human CXCL12/SDF-1 (Accession #NP_000600.1) fused with and a RaFc tag at the C-terminus.
Post Translational Modifications Processed forms SDF-1-beta(3-72) and SDF-1-alpha(3-67) are produced after secretion by proteolytic cleavage of isoforms Beta and Alpha, respectively. The N-terminal processing is probably achieved by DPP4. Isoform Alpha is first cleaved at the C-terminus to yield a SDF-1-alpha(1-67) intermediate before being processed at the N-terminus. The C-terminal processing of isoform Alpha is reduced by binding to heparin and, probably, cell surface proteoglycans.
Function Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development.required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells.
Protein Name Stromal Cell-Derived Factor 1
Sdf-1
Hsdf-1
C-X-C Motif Chemokine 12
Intercrine Reduced In Hepatomas
Irh
Hirh
Pre-B Cell Growth-Stimulating Factor
Pbsf Cleaved Into - Sdf-1-Beta(3-72 - Sdf-1-Alpha(3-67
Database Links Reactome: R-HSA-1251985
Reactome: R-HSA-376176
Reactome: R-HSA-380108
Reactome: R-HSA-418594
Reactome: R-HSA-9018519
Cellular Localisation Secreted
Alternative Protein Names Stromal Cell-Derived Factor 1 protein
Sdf-1 protein
Hsdf-1 protein
C-X-C Motif Chemokine 12 protein
Intercrine Reduced In Hepatomas protein
Irh protein
Hirh protein
Pre-B Cell Growth-Stimulating Factor protein
Pbsf Cleaved Into - Sdf-1-Beta(3-72 - Sdf-1-Alpha(3-67 protein
CXCL12 protein
SDF1 protein
SDF1A protein
SDF1B protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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