产品详情
查看大图

  • 产品名称：Dnmt3a Blocking Peptide for STJ506252 peptide (STJ506255)

  • 产品型号：STJ506255-250
  • 产品厂商：ST john's laboratory
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
Dnmt3a Blocking Peptide for STJ506252 peptide (STJ506255)
详情介绍：
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Dnmt3a Blocking Peptide for STJ506252 is synthetically produced from the 100-150 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Dnmt3a
Gene ID: 13435
Uniprot ID: DNM3A_MOUSE
Immunogen Region: 100-150
Specificity: This blocking peptide is recommended for use in combination with Dnmt3a antibody, STJ506252
Post Translational Modifications Auto-methylated at Cys-706: auto-methylation takes place in absence of DNA substrate and inactivates the DNA methyltransferase activity. Inactivation by auto-methylation may be used to inactivate unused DNA methyltransferases in the cell. Sumoylated.sumoylation disrupts the ability to interact with histone deacetylases (HDAC1 and HDAC2) and repress transcription.
Function Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. Also has weak auto-methylation activity on Cys-706 in absence of DNA.
Peptide Name Dna
Cytosine-5-Methyltransferase 3a
Dnmt3a
Cysteine Methyltransferase Dnmt3a
Dna Methyltransferase Mmuiiia
Dna Mtase Mmuiiia
M.mmuiiia
Database Links Reactome: R-MMU-212300
Reactome: -MMU-3214858
Cellular Localisation Nucleus
Chromosome
Cytoplasm
Accumulates In The Major Satellite Repeats At Pericentric Heterochromatin
Alternative Peptide Names Dna protein
Cytosine-5-Methyltransferase 3a protein
Dnmt3a protein
Cysteine Methyltransferase Dnmt3a protein
Dna Methyltransferase Mmuiiia protein
Dna Mtase Mmuiiia protein
M.mmuiiia protein
Dnmt3a protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
姓名：
电话：
您的需求：
 

沪公网安备 31011002002624号