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  • 产品名称：Human EphA3 protein (Recombinant) (C-His) (STJP001085)

  • 产品型号：STJP001085
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human EphA3 protein (Recombinant) (C-His) (STJP001085)
详情介绍：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human EphA3-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Human EFNA5 at 0.5 Mu g/mL (100 Mu L/well) can bind Human EPHA3 with a linear range of 0.01-0.3 ng/mL.
Gene Symbol: EPHA3
Gene ID: 2042
Uniprot ID: EPHA3_HUMAN
Immunogen Region: Met1-Gln541
Immunogen: Recombinant Human EphA3 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Gln541) of human EphA3 (Accession #NP_005224.2) fused with a 6×His tag at the C-terminus.
Tissue Specificity Widely expressed. Highest level in placenta.
Post Translational Modifications Autophosphorylates upon activation by EFNA5. Phosphorylation on Tyr-602 mediates interaction with NCK1. Dephosphorylated by PTPN1.
Function Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development.
Protein Name Ephrin Type-A Receptor 3
Eph-Like Kinase 4
Ek4
Hek4
Hek
Human Embryo Kinase
Tyrosine-Protein Kinase Tyro4
Tyrosine-Protein Kinase Receptor Etk1
Eph-Like Tyrosine Kinase 1
Database Links Reactome: R-HSA-2682334
Reactome: R-HSA-3928663
Reactome: R-HSA-3928665
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Isoform 2: Secreted
Alternative Protein Names Ephrin Type-A Receptor 3 protein
Eph-Like Kinase 4 protein
Ek4 protein
Hek4 protein
Hek protein
Human Embryo Kinase protein
Tyrosine-Protein Kinase Tyro4 protein
Tyrosine-Protein Kinase Receptor Etk1 protein
Eph-Like Tyrosine Kinase 1 protein
EPHA3 protein
ETK protein
ETK1 protein
HEK protein
TYRO4 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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