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  • 产品名称：Human Fc-gamma RIIb/CD32b protein (Recombinant) (C-His) (STJP000851)

  • 产品型号：STJP000851
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human Fc-gamma RIIb/CD32b protein (Recombinant) (C-His) (STJP000851)
详情介绍：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human Fc-gamma RIIb/CD32b-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human FCGR2B at 2 Mu g/mL (100 Mu L/well) can bind biotinylated Human IgG1 with a linear range of 0.0048-2.81 Mu g/mL.2. Measured by its binding ability in a functional EL
Gene Symbol: FCGR2B
Gene ID: 2213
Uniprot ID: FCG2B_HUMAN
Immunogen: Recombinant Human Fc-gamma RIIb/CD32b Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Ala46-Pro217) of human Fc gamma RIIB/C (Accession #NP_003992.3) fused with a 6×His tag at the C-terminus.
Tissue Specificity Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells.
Post Translational Modifications Phosphorylated by the SRC-type Tyr-kinases LYN and BLK.
Function Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.
Protein Name Low Affinity Immunoglobulin Gamma Fc Region Receptor Ii-B
Igg Fc Receptor Ii-B
Cdw32
Fc-Gamma Rii-B
Fc-Gamma-Riib
Fcrii-B
Cd Antigen Cd32
Database Links Reactome: R-HSA-198933
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Low Affinity Immunoglobulin Gamma Fc Region Receptor Ii-B protein
Igg Fc Receptor Ii-B protein
Cdw32 protein
Fc-Gamma Rii-B protein
Fc-Gamma-Riib protein
Fcrii-B protein
Cd Antigen Cd32 protein
FCGR2B protein
CD32 protein
FCG2 protein
IGFR2 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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