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  • 产品名称：Human CDH5/VE-cadherin protein (Recombinant) (C-hFc&His) (STJP001090)

  • 产品型号：STJP001090
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human CDH5/VE-cadherin protein (Recombinant) (C-hFc&His) (STJP001090)
详情介绍：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human CDH5/VE-cadherin-C-hFc&His protein was developed from hek293 cells and has a target region of C-hFc&His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Gene Symbol: CDH5
Gene ID: 1003
Uniprot ID: CADH5_HUMAN
Immunogen: Recombinant Human CDH5/VE-cadherin Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asp48-Gln593) of human VE-Cadherin (Accession #NP_001786.2) fused with an Fc, 6×His tag at the C-terminus.
Tissue Specificity Endothelial tissues and brain.
Post Translational Modifications Phosphorylated on tyrosine residues by KDR/VEGFR-2. Dephosphorylated by PTPRB. O-glycosylated.
Function Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells.cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 and PALS1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction.
Protein Name Cadherin-5
7b4 Antigen
Vascular Endothelial Cadherin
Ve-Cadherin
Cd Antigen Cd144
Database Links Reactome: R-HSA-418990
Reactome: R-HSA-5218920
Cellular Localisation Cell Junction
Cell Membrane
Single-Pass Type I Membrane Protein
Found At Cell-Cell Boundaries And Probably At Cell-Matrix Boundaries
Krit1 And Cdh5 Reciprocally Regulate Their Localization To Endothelial Cell-Cell Junctions
Alternative Protein Names Cadherin-5 protein
7b4 Antigen protein
Vascular Endothelial Cadherin protein
Ve-Cadherin protein
Cd Antigen Cd144 protein
CDH5 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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