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  • 产品名称：Human Ephrin-A1/EFNA1 protein (Recombinant) (C-His) (STJP002759)

  • 产品型号：STJP002759
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human Ephrin-A1/EFNA1 protein (Recombinant) (C-His) (STJP002759)
详情介绍：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human Ephrin-A1/EFNA1-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Human EFNA1 at 1 Mu g/mL (100 Mu L/well) can bind Human Ephrin A1 Rabbit monoclonal antibody with a linear range of 0.098-2.066 ng/mL.
Gene Symbol: EFNA1
Gene ID: 1942
Uniprot ID: EFNA1_HUMAN
Immunogen Region: Asp19-Ser182
Immunogen: Recombinant Human Ephrin-A1/EFNA1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asp19-Ser182) of human Ephrin-A1/EFNA1 (Accession #NP_004419.2) fused with a 6×His tag at the C-terminus.
Post Translational Modifications Undergoes proteolysis by a metalloprotease to give rise to a soluble monomeric form. N-Glycosylation is required for binding to EPHA2 receptor and inducing its internalization.
Function Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.
Protein Name Ephrin-A1
Eph-Related Receptor Tyrosine Kinase Ligand 1
Lerk-1
Immediate Early Response Protein B61
Tumor Necrosis Factor Alpha-Induced Protein 4
Tnf Alpha-Induced Protein 4 Cleaved Into - Ephrin-A1 - Secreted Form
Database Links Reactome: R-HSA-2682334
Reactome: R-HSA-3928663
Reactome: R-HSA-3928665
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Ephrin-A1
Secreted Form: Secreted
Alternative Protein Names Ephrin-A1 protein
Eph-Related Receptor Tyrosine Kinase Ligand 1 protein
Lerk-1 protein
Immediate Early Response Protein B61 protein
Tumor Necrosis Factor Alpha-Induced Protein 4 protein
Tnf Alpha-Induced Protein 4 Cleaved Into - Ephrin-A1 - Secreted Form protein
EFNA1 protein
EPLG1 protein
LERK1 protein
TNFAIP4 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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