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  • 产品名称：Ephrin Receptor A3 Positive Control peptide (STJ504047)

  • 产品型号：STJ504047-5
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Ephrin Receptor A3 Positive Control peptide (STJ504047)
详情介绍：
Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Ephrin Receptor A3 Positive Control is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range: WB: 1:500
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: EPHA3
Gene ID: 2042
Uniprot ID: EPHA3_HUMAN
Tissue Specificity Widely expressed. Highest level in placenta.
Post Translational Modifications Autophosphorylates upon activation by EFNA5. Phosphorylation on Tyr-602 mediates interaction with NCK1. Dephosphorylated by PTPN1.
Function Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development.
Peptide Name Ephrin Type-A Receptor 3
Eph-Like Kinase 4
Ek4
Hek4
Hek
Human Embryo Kinase
Tyrosine-Protein Kinase Tyro4
Tyrosine-Protein Kinase Receptor Etk1
Eph-Like Tyrosine Kinase 1
Database Links Reactome: R-HSA-2682334
Reactome: R-HSA-3928663
Reactome: R-HSA-3928665
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Isoform 2: Secreted
Alternative Peptide Names Ephrin Type-A Receptor 3 protein
Eph-Like Kinase 4 protein
Ek4 protein
Hek4 protein
Hek protein
Human Embryo Kinase protein
Tyrosine-Protein Kinase Tyro4 protein
Tyrosine-Protein Kinase Receptor Etk1 protein
Eph-Like Tyrosine Kinase 1 protein
EPHA3 protein
ETK protein
ETK1 protein
HEK protein
TYRO4 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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