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  • 产品名称：Ephrin Receptor B3 Blocking Peptide for STJ500938 peptide (STJ504019)

  • 产品型号：STJ504019-250
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Ephrin Receptor B3 Blocking Peptide for STJ500938 peptide (STJ504019)
详情介绍：
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Ephrin Receptor B3 Blocking Peptide for STJ500938 is synthetically produced from the 100-200 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Ephb3
Gene ID: 13845
Uniprot ID: EPHB3_MOUSE
Immunogen Region: 100-200
Specificity: This blocking peptide is recommended for use in combination with Ephrin Receptor B3 antibody, STJ500938
Immunogen: Synthetic peptide taken within amino acid region 100-200 on EphBR3 protein.
Tissue Specificity Expressed in cells of the retinal ganglion cell layer during retinal axon guidance to the optic disk. Expressed by Paneth and progenitor cells in the crypts of the intestinal epithelium (at protein level). Expressed in myogenic progenitor cells.
Post Translational Modifications Phosphorylated. Autophosphorylates upon ligand-binding. Autophosphorylation on Tyr-609 is required for interaction with SH2 domain-containing proteins. Ubiquitinated by RNF186, mainly through 'Lys-48' and 'Lys-63'-linked polyubiquitin chains.
Function Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance also plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epithelium development for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from differentiated cells in the crypt.
Peptide Name Ephrin Type-B Receptor 3
Developmental Kinase 5
Mdk-5
Tyrosine-Protein Kinase Receptor Sek-4
Database Links Reactome: R-MMU-2682334
Reactome: -MMU-3928662
Reactome: -MMU-3928664
Reactome: -MMU-3928665
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cell Projection
Dendrite
Alternative Peptide Names Ephrin Type-B Receptor 3 protein
Developmental Kinase 5 protein
Mdk-5 protein
Tyrosine-Protein Kinase Receptor Sek-4 protein
Ephb3 protein
Etk2 protein
Mdk5 protein
Sek4 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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