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  • 产品名称：ETS1 associated protein II Blocking Peptide peptide (STJ504983)

  • 产品型号：STJ504983-250
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
ETS1 associated protein II Blocking Peptide peptide (STJ504983)
详情介绍：
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: ETS1 associated protein II Blocking Peptide is synthetically produced from the 330-360 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: TDP2
Gene ID: 51567
Uniprot ID: TYDP2_HUMAN
Immunogen Region: 330-360
Immunogen: Synthetic peptide taken within amino acid region 330-360 on human Tyrosyl-DNA phosphodiesterase protein.
Tissue Specificity Widely expressed. Highly expressed in various brain regions, including the frontal and occipital lobes, the hippocampus, the striatum and the cerebellum.
Post Translational Modifications Ubiquitinated by TRAF6.
Function DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DNA double-strand breaks/DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Thereby, protects the transcription of many genes involved in neurological development and maintenance from the abortive activity of TOP2. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DSBs due to DNA damage by radiation and free radicals. Has preference for single-stranded DNA or duplex DNA with a 4 base pair overhang as substrate. Acts as a regulator of ribosome biogenesis following stress. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. Constitutes the major if not only 5'-tyrosyl-DNA phosphodiesterase in cells. Also acts as an adapter by participating in the specific activation of MAP3K7/TAK1 in response to TGF-beta: associates with components of the TGF-beta receptor-TRAF6-TAK1 signaling module and promotes their ubiquitination dependent complex formation. Involved in non-canonical TGF-beta induced signaling routes. May also act as a negative regulator of ETS1 and may inhibit NF-kappa-B activation. (Microbial infection) Also acts as a 5'-tyrosyl-RNA phosphodiesterase following picornavirus infection: its activity is hijacked by picornavirus and acts by specifically cleaving the protein-RNA covalent linkage generated during the viral genomic RNA replication steps of a picornavirus infection, without impairing the integrity of viral RNA.
Peptide Name Tyrosyl-Dna Phosphodiesterase 2
Tyr-Dna Phosphodiesterase 2
Htdp2
5'-Tyrosyl-Dna Phosphodiesterase
5'-Tyr-Dna Phosphodiesterase
Ets1-Associated Protein 2
Ets1-Associated Protein Ii
Eapii
Traf And Tnf Receptor-Associated Protein
Tyrosyl-Rna Phosphodiesterase
Vpg Unlinkase
Database Links Reactome: R-HSA-5693571
Cellular Localisation Nucleus
Pml Body
Nucleolus
Cytoplasm
Localizes To Nucleolar Cavities Following Stress
Localization To Nucleolus Is Dependent On Pml Protein
(Microbial Infection) In Case Of Infection By Picornavirus
Relocalizes To Cytoplasmic Sites Distinct From Those Containing Viral Proteins Associated With Rna Replication Or Encapsidation
Alternative Peptide Names Tyrosyl-Dna Phosphodiesterase 2 protein
Tyr-Dna Phosphodiesterase 2 protein
Htdp2 protein
5'-Tyrosyl-Dna Phosphodiesterase protein
5'-Tyr-Dna Phosphodiesterase protein
Ets1-Associated Protein 2 protein
Ets1-Associated Protein Ii protein
Eapii protein
Traf And Tnf Receptor-Associated Protein protein
Tyrosyl-Rna Phosphodiesterase protein
Vpg Unlinkase protein
TDP2 protein
EAP2 protein
TTRAP protein
AD-022 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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