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  • 产品名称：Human Glypican-1/GPC1 protein (Recombinant) (C-His) (STJP002617)

  • 产品型号：STJP002617
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human Glypican-1/GPC1 protein (Recombinant) (C-His) (STJP002617)
详情介绍：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human Glypican-1/GPC1-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Human FGF2 at 1 Mu g/mL (100 Mu L/well) can bind Human Glypican 1 with a linear range of 2-80 ng/mL.
Gene Symbol: GPC1
Gene ID: 2817
Uniprot ID: GPC1_HUMAN
Immunogen Region: Asp24-Gln527
Immunogen: Recombinant Human Glypican-1/GPC1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asp24-Gln527) of human Glypican 1 (Accession #NP_002072.1) fused with a 6×His tag at the C-terminus.
Function Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination. May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling.
Protein Name Glypican-1 Cleaved Into - Secreted Glypican-1
Database Links Reactome: R-HSA-1971475
Reactome: R-HSA-2022928
Reactome: R-HSA-2024096
Reactome: R-HSA-202733
Reactome: R-HSA-3560783
Reactome: R-HSA-3560801
Reactome: R-HSA-3656237
Reactome: R-HSA-3656253
Reactome: R-HSA-376176
Reactome: R-HSA-4420332
Reactome: R-HSA-9694614
Reactome: R-HSA-975634
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Extracellular Side
Endosome
S-Nitrosylated Form Recycled In Endosomes
Localizes To Cav1-Containing Vesicles Close To The Cell Surface
Cleavage Of Heparan Sulfate Side Chains Takes Place Mainly In Late Endosomes
Associates With Both Forms Of Prnp In Lipid Rafts
Colocalizes With App In Perinuclear Compartments And With Cp In Intracellular Compartments
Associates With Fibrillar App Amyloid-Beta Peptides In Lipid Rafts In Alzheimer Disease Brains
Secreted Glypican-1: Secreted
Extracellular Space
Alternative Protein Names Glypican-1 Cleaved Into - Secreted Glypican-1 protein
GPC1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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