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  • 产品名称：Human IGF2BP2 protein (Recombinant) (STJP001871)

  • 产品型号：STJP001871
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human IGF2BP2 protein (Recombinant) (STJP001871)
详情介绍：
Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human IGF2BP2-protein was developed from hek293. For use in research applications.
Conjugation: Unconjugated
Formulation: Lyophilised from 0.2 Mu m filtered PBS solution, pH7.2, 5% Trehalose.
Storage Instruction: Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA
Gene Symbol: IGF2BP2
Gene ID: 10644
Uniprot ID: IF2B2_HUMAN
Immunogen Region: MET1-LYS599
Immunogen: Optimized DNA sequence encoding peptidase domain of Human Hypoxia inducible factor 1 alpha (MET1-LYS599) including a C-terminal His tag was expressed in HEK cells NA
Tissue Specificity Expressed in oocytes, granulosa cells of small and growing follicles, Leydig cells, spermatogonia and semen (at protein level). Expressed in testicular cancer (at protein level). Expressed weakly in heart, placenta, skeletal muscle, bone marrow, colon, kidney, salivary glands, testis and pancreas. Detected in fetal liver, fetal ovary, gonocytes and interstitial cells of the testis.
Function RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD.
Protein Name Insulin-Like Growth Factor 2 Mrna-Binding Protein 2
Igf2 Mrna-Binding Protein 2
Imp-2
Hepatocellular Carcinoma Autoantigen P62
Igf-Ii Mrna-Binding Protein 2
Vickz Family Member 2
Database Links Reactome: R-HSA-428359
Cellular Localisation Nucleus
Cytoplasm
P-Body
Stress Granule
Localized In Cytoplasmic Mrnp Granules Containing Untranslated Mrnas
Localizes At The Connecting Piece And The Tail Of The Spermatozoa
In Response To Cellular Stress
Such As Oxidative Stress
Recruited To Stress Granules
Alternative Protein Names Insulin-Like Growth Factor 2 Mrna-Binding Protein 2 protein
Igf2 Mrna-Binding Protein 2 protein
Imp-2 protein
Hepatocellular Carcinoma Autoantigen P62 protein
Igf-Ii Mrna-Binding Protein 2 protein
Vickz Family Member 2 protein
IGF2BP2 protein
IMP2 protein
VICKZ2 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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