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  • 产品名称：Human a2ML1 (Alpha-2-Microglobulin Like Protein 1) Sandwich ELISA Kit (STJE0006797)

  • 产品型号：STJE0006797
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human a2ML1 (Alpha-2-Microglobulin Like Protein 1) Sandwich ELISA Kit (STJE0006797)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.067ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This a2ML1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: A2ML1
Gene ID: 144568
Uniprot ID: A2ML1_HUMAN
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity In the epidermis, expressed predominantly in the granular layer at the apical edge of keratinocytes (at protein level). Also detected in placenta, testis and thymus but not in epithelia of kidney, lung, small intestine or colon.
Post Translational Modifications
Function Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. Displays inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but not trypsin. May play an important role during desquamation by inhibiting extracellular proteases.
Protein Name Alpha-2-Macroglobulin-Like Protein 1
C3 And Pzp-Like Alpha-2-Macroglobulin Domain-Containing Protein 9
Database Links
Cellular Localisation Secreted
Alternative ELISA Names Alpha-2-Macroglobulin-Like Protein 1 ELISA kit
C3 And Pzp-Like Alpha-2-Macroglobulin Domain-Containing Protein 9 ELISA kit
A2ML1 ELISA kit
CPAMD9 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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