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  • 产品名称：Human ABCC6 (ATP Binding Cassette Transporter C6) Sandwich ELISA Kit Ready-To-Use (STJE0013200)

  • 产品型号：STJE0013200
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human ABCC6 (ATP Binding Cassette Transporter C6) Sandwich ELISA Kit Ready-To-Use (STJE0013200)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.126ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This ABCC6 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: ABCC6
Gene ID: 368
Uniprot ID: MRP6_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Expressed in kidney and liver. Very low expression in other tissues. In testis, localized to peritubular myoid cells, Leydig cells, along the basal membrane of Sertoli cells and moderately in the adluminal compartment of the seminiferous tubules.
Post Translational Modifications Glycosylated.
Function Isoform 1: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of glutathione conjugates such as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) (in vitro), and an anionic cyclopentapeptide endothelin antagonist, BQ-123. May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Does not appear to actively transport drugs outside the cell. Confers low levels of cellular resistance to etoposide, teniposide, anthracyclines and cisplatin. Isoform 1: Mediates the release of nucleoside triphosphates, predominantly ATP, into the circulation, where it is rapidly converted into AMP and the mineralization inhibitor inorganic pyrophosphate (PPi) by the ecto-enzyme ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), therefore playing a role in PPi homeostasis. Isoform 2: Inhibits TNF-alpha-mediated apoptosis through blocking one or more caspases.
Protein Name Atp-Binding Cassette Sub-Family C Member 6
Anthracycline Resistance-Associated Protein
Multi-Specific Organic Anion Transporter E
Moat-E
Multidrug Resistance-Associated Protein 6
Database Links Reactome: R-HSA-382556
Reactome: R-HSA-5690338
Cellular Localisation Basal Cell Membrane
Multi-Pass Membrane Protein
Localized To The Basal Membrane Of Sertoli Cells
Isoform 1: Basolateral Cell Membrane
Isoform 2: Endoplasmic Reticulum Membrane
Single-Pass Membrane Protein
Alternative ELISA Names Atp-Binding Cassette Sub-Family C Member 6 ELISA kit
Anthracycline Resistance-Associated Protein ELISA kit
Multi-Specific Organic Anion Transporter E ELISA kit
Moat-E ELISA kit
Multidrug Resistance-Associated Protein 6 ELISA kit
ABCC6 ELISA kit
ARA ELISA kit
MRP6 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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