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  • 产品名称：Human IL-1 receptor 1 (CD121a) protein (Recombinant) (STJP000430)

  • 产品型号：STJP000430
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human IL-1 receptor 1 (CD121a) protein (Recombinant) (STJP000430)
详情介绍：
Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human IL-1 receptor 1 (CD121a)-protein was developed from hek293. For use in research applications.
Conjugation: Unconjugated
Formulation: Lyophilised from 0.2 Mu m filtered PBS solution, pH7.2, 5% Trehalose.
Storage Instruction: Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA
Immunoreactivity: Measured by its ability to bind recombinant human Interleukin-1 beta. NA
Gene Symbol: IL1R1
Gene ID: 3554
Uniprot ID: IL1R1_HUMAN
Immunogen Region: ECD
Immunogen: Optimized DNA sequence encoding Human extracellular domain of human IL-1 receptor including a C-terminal Fc tag was expressed in HEK293 cells. NA
Tissue Specificity Expressed in T-helper cell subsets. Preferentially expressed in T-helper 1 (Th1) cells.
Post Translational Modifications A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding). Rapidly phosphorylated on Tyr-496 in response to IL-1, which creates a SH2 binding site for the PI 3-kinase regulatory subunit PIK3R1.
Function Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells.
Protein Name Interleukin-1 Receptor Type 1
Il-1r-1
Il-1rt-1
Il-1rt1
Cd121 Antigen-Like Family Member A
Interleukin-1 Receptor Alpha
Il-1r-Alpha
Interleukin-1 Receptor Type I
P80
Cd Antigen Cd121a Cleaved Into - Interleukin-1 Receptor Type 1 - Membrane Form
Mil-1r1
Mil-1ri - Interleukin-1 Receptor Type 1 - Soluble Form
Sil-1r1
Sil-1ri
Database Links Reactome: R-HSA-6783783
Reactome: R-HSA-9020702
Reactome: R-HSA-9679191
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Cell Membrane
Secreted
Alternative Protein Names Interleukin-1 Receptor Type 1 protein
Il-1r-1 protein
Il-1rt-1 protein
Il-1rt1 protein
Cd121 Antigen-Like Family Member A protein
Interleukin-1 Receptor Alpha protein
Il-1r-Alpha protein
Interleukin-1 Receptor Type I protein
P80 protein
Cd Antigen Cd121a Cleaved Into - Interleukin-1 Receptor Type 1 - Membrane Form protein
Mil-1r1 protein
Mil-1ri - Interleukin-1 Receptor Type 1 - Soluble Form protein
Sil-1r1 protein
Sil-1ri protein
IL1R1 protein
IL1R protein
IL1RA protein
IL1RT1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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