产品详情
查看大图

  • 产品名称：Human IL-12A protein (Recombinant) (C-hFc&His) (STJP000948)

  • 产品型号：STJP000948
  • 产品厂商：ST john's laboratory
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
Human IL-12A protein (Recombinant) (C-hFc&His) (STJP000948)
详情介绍：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human IL-12A-C-hFc&His protein was developed from hek293 cells and has a target region of C-hFc&His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Gene Symbol: IL12A
Gene ID: 3592
Uniprot ID: IL12A_HUMAN
Immunogen Region: Arg23-Ser219
Immunogen: Recombinant Human IL-12A Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Arg23-Ser219) of human IL12A/NKSF1 (Accession #NP_002178.2) fused with an Fc, 6×His tag at the C-terminus.
Function Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity. Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits. Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2. In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes. As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine. Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers. Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites.
Protein Name Interleukin-12 Subunit Alpha
Il-12a
Cytotoxic Lymphocyte Maturation Factor 35 Kda Subunit
Clmf P35
Il-12 Subunit P35
Nk Cell Stimulatory Factor Chain 1
Nksf1
Database Links Reactome: R-HSA-6783783
Reactome: R-HSA-6785807
Reactome: R-HSA-8984722
Reactome: R-HSA-9020591
Cellular Localisation Secreted
Alternative Protein Names Interleukin-12 Subunit Alpha protein
Il-12a protein
Cytotoxic Lymphocyte Maturation Factor 35 Kda Subunit protein
Clmf P35 protein
Il-12 Subunit P35 protein
Nk Cell Stimulatory Factor Chain 1 protein
Nksf1 protein
IL12A protein
NKSF1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
姓名：
电话：
您的需求：
 

沪公网安备 31011002002624号