产品详情
简单介绍:
GPIP137 Positive Control peptide (STJ503919)
详情介绍:
Applications: | WB |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | GPIP137 Positive Control is synthetically produced from the sequence and is suitable for use in western blot applications. |
Formulation: | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
Dilution Range: | WB: 1:500 |
Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Gene Symbol: | CAPRIN1 |
Gene ID: | 4076 |
Uniprot ID: | CAPR1_HUMAN |
Tissue Specificity | Ubiquitous. |
Post Translational Modifications | Tyrosine phosphorylation by EPHA4 promotes interaction with FMR1 and liquid-liquid phase separation (LLPS) for the formation of a membraneless compartment that concentrates mRNAs with associated regulatory factors. O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner. O-glycosylation by OGT inhibit ability to undergo liquid-liquid phase separation (LLPS). |
Function | mRNA-binding protein that acts as a regulator of mRNAs transport, translation and/or stability, and which is involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors. Undergoes liquid-liquid phase separation following phosphorylation and interaction with FMR1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs. In these cytoplasmic ribonucleoprotein granules, CAPRIN1 mediates recruitment of CNOT7 deadenylase, leading to mRNA deadenylation and degradation. Binds directly and selectively to MYC and CCND2 mRNAs. In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs. |
Peptide Name | Caprin-1 Cell Cycle-Associated Protein 1 Cytoplasmic Activation- And Proliferation-Associated Protein 1 Gpi-Anchored Membrane Protein 1 Gpi-Anchored Protein P137 Gpi-P137 P137gpi Membrane Component Chromosome 11 Surface Marker 1 Rna Granule Protein 105 |
Cellular Localisation | Cytoplasm Cytoplasmic Ribonucleoprotein Granule Cytosol Cell Projection Dendrite Lamellipodium Mediates Formation And Localizes To Cytoplasmic Ribonucleoprotein Membraneless Compartments Associated With Rna Granules At The Leading Edge Of Migrating Fibroblasts Colocalizes With Ddx3x |
Alternative Peptide Names | Caprin-1 protein Cell Cycle-Associated Protein 1 protein Cytoplasmic Activation- And Proliferation-Associated Protein 1 protein Gpi-Anchored Membrane Protein 1 protein Gpi-Anchored Protein P137 protein Gpi-P137 protein P137gpi protein Membrane Component Chromosome 11 Surface Marker 1 protein Rna Granule Protein 105 protein CAPRIN1 protein GPIAP1 protein GPIP137 protein M11S1 protein RNG105 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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