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  • 产品名称：Human IL-15RA/CD215 protein (Recombinant) (C-hFc&His) (STJP001206)

  • 产品型号：STJP001206
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human IL-15RA/CD215 protein (Recombinant) (C-hFc&His) (STJP001206)
详情介绍：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human IL-15RA/CD215-C-hFc&His protein was developed from hek293 cells and has a target region of C-hFc&His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized recombinant Human IL15 at 2 Mu g/mL (100 Mu L/well) can bind recombinant Human IL-15R alpha, the EC50 of Human IL-15R alpha is 178.9 ng/mL.
Gene Symbol: IL15RA
Gene ID: 3601
Uniprot ID: I15RA_HUMAN
Immunogen: Recombinant Human IL-15RA/CD215 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Thr205) of human IL-15R alpha/CD215 (Accession #NP_002180.1) fused with a Fc, 6×His tag at the C-terminus.
Post Translational Modifications N-glycosylated and O-glycosylated. A soluble form (sIL-15RA) arises from proteolytic shedding of the membrane-anchored receptor. It also binds IL-15 and thus interferes with IL-15 binding to the membrane receptor.
Function High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. In neutrophils, binds and activates kinase SYK in response to IL15 stimulation. In neutrophils, required for IL15-induced phagocytosis in a SYK-dependent manner. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5: Does not bind IL15. Isoform 6: Does not bind IL15. Isoform 7: Does not bind IL15. Isoform 8: Does not bind IL15.
Protein Name Interleukin-15 Receptor Subunit Alpha
Il-15 Receptor Subunit Alpha
Il-15r-Alpha
Il-15ra
Cd Antigen Cd215 Cleaved Into - Soluble Interleukin-15 Receptor Subunit Alpha
Sil-15 Receptor Subunit Alpha
Sil-15r-Alpha
Sil-15ra
Database Links Reactome: R-HSA-8983432
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Nucleus Membrane
Cell Surface
Mainly Found Associated With The Nuclear Membrane
Isoform 5: Endoplasmic Reticulum Membrane
Golgi Apparatus Membrane
Cytoplasmic Vesicle Membrane
Isoform 5
Isoform 6
Isoform 7 And Isoform 8 Are Associated With Endoplasmic Reticulum
Golgi And Cytoplasmic Vesicles
But Not With The Nuclear Membrane
Isoform 6: Endoplasmic Reticulum Membrane
Isoform 7: Endoplasmic Reticulum Membrane
Isoform 8: Endoplasmic Reticulum Membrane
Soluble Interleukin-15 Receptor Subunit Alpha: Secreted
Extracellular Space
Alternative Protein Names Interleukin-15 Receptor Subunit Alpha protein
Il-15 Receptor Subunit Alpha protein
Il-15r-Alpha protein
Il-15ra protein
Cd Antigen Cd215 Cleaved Into - Soluble Interleukin-15 Receptor Subunit Alpha protein
Sil-15 Receptor Subunit Alpha protein
Sil-15r-Alpha protein
Sil-15ra protein
IL15RA protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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