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  • 产品名称：Human IL-1R3/IL-1RAcP/IL1RAP protein (Recombinant) (C-hFc) (STJP001374)

  • 产品型号：STJP001374
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human IL-1R3/IL-1RAcP/IL1RAP protein (Recombinant) (C-hFc) (STJP001374)
详情介绍：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human IL-1R3/IL-1RAcP/IL1RAP-C-hFc protein was developed from hek293 cells and has a target region of C-hFc. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Gene Symbol: IL1RAP
Gene ID: 3556
Uniprot ID: IL1AP_HUMAN
Immunogen: Recombinant Human IL-1R3/IL-1RAcP/IL1RAP Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser21-Glu359) of human IL1RAP/IL1R3 (Accession #NP_002173.1) fused with a hFc tag at the C-terminus.
Function Coreceptor for IL1RL2 in the IL-36 signaling system. Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone.binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD. May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (Probable). Isoform 2: Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B.this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling. Isoform 4: Unable to mediate canonical IL-1 signaling. Required for Src phosphorylation by IL1B. May be involved in IL1B-potentiated NMDA-induced calcium influx in neurons.
Protein Name Interleukin-1 Receptor Accessory Protein
Il-1 Receptor Accessory Protein
Il-1racp
Interleukin-1 Receptor 3
Il-1r-3
Il-1r3
Database Links Reactome: R-HSA-1257604 Q9NPH3-1
Reactome: R-HSA-388844 Q9NPH3-1
Reactome: R-HSA-6811558 Q9NPH3-1
Reactome: R-HSA-9014826 Q9NPH3-1
Reactome: R-HSA-9014843 Q9NPH3-1
Reactome: R-HSA-9020702 Q9NPH3-1
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Isoform 2: Secreted
Isoform 3: Secreted
Alternative Protein Names Interleukin-1 Receptor Accessory Protein protein
Il-1 Receptor Accessory Protein protein
Il-1racp protein
Interleukin-1 Receptor 3 protein
Il-1r-3 protein
Il-1r3 protein
IL1RAP protein
C3orf13 protein
IL1R3 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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