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  • 产品名称：Anti-AGT antibody (35-485) (STJ118084)

  • 产品型号：STJ118084
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-AGT antibody (35-485) (STJ118084)
详情介绍：
Host: Rabbit
Applications: WB/IHC/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-AGT (35-485) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
IHC-P 1:50-1:100
IF/ICC 1:50-1:100
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: AGT
Gene ID: 183
Uniprot ID: ANGT_HUMAN
Immunogen Region: 35-485
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 35-485 of human Angiotensinogen (NP_000020.1).
Immunogen Sequence: RVYIHPFHLVIHNESTCEQL AKANAGKPKDPTFIPAPIQA KTSPVDEKALQDQLVLVAAK LDTEDKLRAAMVGMLANFLG FRIYGMHSELWGVVHGATVL SPTAVFGTLASLYLGALDHT ADRLQAILGVPWKDKNCTSR LDAHKVLSALQAVQGLLVAQ GRADSQAQLLLSTVVGVFTA PGLHLKQPFVQGLALYTPVV LPRSLDFTELDVAAEKIDRF MQAVTGWKTGCSLMGASVD
Tissue Specificity Expressed by the liver and secreted in plasma.
Post Translational Modifications Beta-decarboxylation of Asp-34 in angiotensin-2, by mononuclear leukocytes produces alanine. The resulting peptide form, angiotensin-A, has the same affinity for the AT1 receptor as angiotensin-2, but a higher affinity for the AT2 receptor. In response to low blood pressure, the enzyme renin/REN cleaves angiotensinogen to produce angiotensin-1. Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3, angiotensin-4. Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2 and can be further processed by ACE to produce angiotensin 1-7, angiotensin 1-5 and angiotensin 1-4. Angiotensin 1-7 has also been proposed to be cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin). The disulfide bond is labile. Angiotensinogen is present in the circulation in a near 40:60 ratio with the oxidized disulfide-bonded form, which preferentially interacts with receptor-bound renin.
Function Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. Angiotensin-2: Acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. Acts by binding to angiotensin receptors AGTR1 and AGTR2. Also binds the DEAR/FBXW7-AS1 receptor. Angiotensin-3: Stimulates aldosterone release. Angiotensin 1-7: Is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.
Protein Name Angiotensinogen
Serpin A8 Cleaved Into - Angiotensin-1
Angiotensin 1-10
Angiotensin I
Ang I - Angiotensin-2
Angiotensin 1-8
Angiotensin Ii
Ang Ii - Angiotensin-3
Angiotensin 2-8
Angiotensin Iii
Ang Iii
Des-Asp1-Angiotensin Ii - Angiotensin-4
Angiotensin 3-8
Angiotensin Iv
Ang Iv - Angiotensin 1-9 - Angiotensin 1-7 - Angiotensin 1-5 - Angiotensin 1-4
Database Links Reactome: R-HSA-1989781
Reactome: R-HSA-2022377
Reactome: R-HSA-375276
Reactome: R-HSA-416476
Reactome: R-HSA-418594
Cellular Localisation Secreted
Alternative Antibody Names Anti-Angiotensinogen antibody
Anti-Serpin A8 Cleaved Into - Angiotensin-1 antibody
Anti-Angiotensin 1-10 antibody
Anti-Angiotensin I antibody
Anti-Ang I - Angiotensin-2 antibody
Anti-Angiotensin 1-8 antibody
Anti-Angiotensin Ii antibody
Anti-Ang Ii - Angiotensin-3 antibody
Anti-Angiotensin 2-8 antibody
Anti-Angiotensin Iii antibody
Anti-Ang Iii antibody
Anti-Des-Asp1-Angiotensin Ii - Angiotensin-4 antibody
Anti-Angiotensin 3-8 antibody
Anti-Angiotensin Iv antibody
Anti-Ang Iv - Angiotensin 1-9 - Angiotensin 1-7 - Angiotensin 1-5 - Angiotensin 1-4 antibody
Anti-AGT antibody
Anti-SERPINA8 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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