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  • 产品名称：Anti-AhR antibody (619-848) [S4MR] (STJ11103544)

  • 产品型号：STJ11103544
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-AhR antibody (619-848) [S4MR] (STJ11103544)
详情介绍：
Host: Rabbit
Applications: WB/IHC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-AhR (619-848) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: S4MR
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
IHC-P 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: AHR
Gene ID: 196
Uniprot ID: AHR_HUMAN
Immunogen Region: 619-848
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 619-848 of human AHR (NP_001612.1).
Immunogen Sequence: LEQQQQHHQKQVVVEPQQQL CQKMKHMQVNGMFENWNSNQ FVPFNCPQQDPQQYNVFTDL HGISQEFPYKSEMDSMPYTQ NFISCNQPVLPQHSKCTELD YPMGSFEPSPYPTTSSLEDF VTCLQLPENQKHGLNPQSAI ITPQTCYAGAVSMYQCQPEP QHTHVGQMQYNPVLPGQQAF LNKFQNGVLNETYPAELNNI NNTQTTTHLQPLHHPSEARP FPDLTSSGFL
Tissue Specificity Expressed in all tissues tested including blood, brain, heart, kidney, liver, lung, pancreas and skeletal muscle. Expressed in retinal photoreceptors.
Post Translational Modifications Mono-ADP-ribosylated, leading to inhibit transcription activator activity of AHR.
Function Ligand-activated transcription factor that enables cells to adapt to changing conditions by sensing compounds from the environment, diet, microbiome and cellular metabolism, and which plays important roles in development, immunity and cancer. Upon ligand binding, translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE). Regulates a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation. Xenobiotics can act as ligands: upon xenobiotic-binding, activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Next to xenobiotics, natural ligands derived from plants, microbiota, and endogenous metabolism are potent AHR agonists. Tryptophan (Trp) derivatives constitute an important class of endogenous AHR ligands. Acts as a negative regulator of anti-tumor immunity: indoles and kynurenic acid generated by Trp catabolism act as ligand and activate AHR, thereby promoting AHR-driven cancer cell motility and suppressing adaptive immunity. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-BMAL1 heterodimer mediated transcriptional activation of PER1. The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription.
Protein Name Aryl Hydrocarbon Receptor
Ah Receptor
Ahr
Class E Basic Helix-Loop-Helix Protein 76
Bhlhe76
Database Links Reactome: R-HSA-1989781
Reactome: R-HSA-211945
Reactome: R-HSA-211976
Reactome: R-HSA-211981
Reactome: R-HSA-8937144
Cellular Localisation Cytoplasm
Nucleus
Initially Cytoplasmic
Upon Binding With Ligand And Interaction With A Hsp90
It Translocates To The Nucleus
Alternative Antibody Names Anti-Aryl Hydrocarbon Receptor antibody
Anti-Ah Receptor antibody
Anti-Ahr antibody
Anti-Class E Basic Helix-Loop-Helix Protein 76 antibody
Anti-Bhlhe76 antibody
Anti-AHR antibody
Anti-BHLHE76 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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