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  • 产品名称：Anti-AICDA antibody (17-130) (STJ114250)

  • 产品型号：STJ114250
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-AICDA antibody (17-130) (STJ114250)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-AICDA (17-130) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: AICDA
Gene ID: 57379
Uniprot ID: AICDA_HUMAN
Immunogen Region: 17-130
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 17-130 of human AICDA (NP_065712.1).
Immunogen Sequence: NVRWAKGRRETYLCYVVKRR DSATSFSLDFGYLRNKNGCH VELLFLRYISDWDLDPGRCY RVTWFTSWSPCYDCARHVAD FLRGNPNLSLRIFTARLYFC EDRKAEPEGLRRLH
Tissue Specificity Strongly expressed in lymph nodes and tonsils.
Post Translational Modifications Ser-38 is the major site whereas Thr-27 is the minor site of phosphorylation. Phosphorylation regulates its class-switch recombination activity. Probably monoubiquitinated on several residues by RNF126.
Function Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.
Protein Name Single-Stranded Dna Cytosine Deaminase
Activation-Induced Cytidine Deaminase
Aid
Cytidine Aminohydrolase
Cellular Localisation Nucleus
Cytoplasm
Cytosol
Predominantly Cytosolic
In The Presence Of Mcm3ap/Ganp
Relocalizes To The Nucleus
Alternative Antibody Names Anti-Single-Stranded Dna Cytosine Deaminase antibody
Anti-Activation-Induced Cytidine Deaminase antibody
Anti-Aid antibody
Anti-Cytidine Aminohydrolase antibody
Anti-AICDA antibody
Anti-AID antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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