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  • 产品名称：Human IL-6RB/gp130/CD130 protein (Recombinant) (C-hFc&His) (STJP001228)

  • 产品型号：STJP001228
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human IL-6RB/gp130/CD130 protein (Recombinant) (C-hFc&His) (STJP001228)
详情介绍：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human IL-6RB/gp130/CD130-C-hFc&His protein was developed from hek293 cells and has a target region of C-hFc&His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Gene Symbol: IL6ST
Gene ID: 3572
Uniprot ID: IL6RB_HUMAN
Immunogen: Recombinant Human IL-6RB/gp130/CD130 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Ile618) of human gp130/CD130/IL-6 R beta (Accession #NP_002175.2) fused with a Fc, 6×His tag at the C-term
Post Translational Modifications Phosphorylation of Ser-782 down-regulates cell surface expression. Heavily N-glycosylated. Glycosylation is required for protein stability and localization in plasma membrane but not for ligand binding.
Function Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates the intracellular JAK-MAPK and JAK-STAT3 signaling pathways. That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3. In parallel, the IL6 signaling pathway induces the expression of two cytokine receptor signaling inhibitors, SOCS1 and SOCS3, which inhibit JAK and terminate the activity of the IL6 signaling pathway as a negative feedback loop. Also activates the yes-associated protein 1 (YAP) and NOTCH pathways to control inflammation-induced epithelial regeneration, independently of STAT3. Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL27RA/WSX1 and CNTFR. Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism. Has a role in embryonic development. Essential for survival of motor and sensory neurons and for differentiation of astrocytes. Required for expression of TRPA1 in nociceptive neurons. Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation. Required for normal trabecular bone mass and cortical bone composition. Isoform 2: Binds to the soluble IL6:sIL6R complex (hyper-IL6), thereby blocking IL6 trans-signaling. Inhibits sIL6R-dependent acute phase response. Also blocks IL11 cluster signaling through IL11R.
Protein Name Interleukin-6 Receptor Subunit Beta
Il-6 Receptor Subunit Beta
Il-6r Subunit Beta
Il-6r-Beta
Il-6rb
Cdw130
Interleukin-6 Signal Transducer
Membrane Glycoprotein 130
Gp130
Oncostatin-M Receptor Subunit Alpha
Cd Antigen Cd130
Database Links Reactome: R-HSA-1059683
Reactome: R-HSA-110056 P40189-1
Reactome: R-HSA-112411 P40189-1
Reactome: R-HSA-6788467
Reactome: R-HSA-8984722
Reactome: R-HSA-9020956
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Isoform 2: Secreted
Alternative Protein Names Interleukin-6 Receptor Subunit Beta protein
Il-6 Receptor Subunit Beta protein
Il-6r Subunit Beta protein
Il-6r-Beta protein
Il-6rb protein
Cdw130 protein
Interleukin-6 Signal Transducer protein
Membrane Glycoprotein 130 protein
Gp130 protein
Oncostatin-M Receptor Subunit Alpha protein
Cd Antigen Cd130 protein
IL6ST protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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