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  • 产品名称：Anti-AIMP1 antibody (25-180) (STJ27254)

  • 产品型号：STJ27254
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-AIMP1 antibody (25-180) (STJ27254)
详情介绍：
Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-AIMP1 (25-180) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IHC-P 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: AIMP1
Gene ID: 9255
Uniprot ID: AIMP1_HUMAN
Immunogen Region: 25-180
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 25-180 of human AIMP1 (NP_001135888.1).
Immunogen Sequence: MANNDAVLKRLEQKGAEADQ IIEYLKQQVSLLKEKAILQA TLREEKKLRVENAKLKKEIE ELKQELIQAEIQNGVKQIPF PSGTPLHANSMVSENVIQST AVTTVSSGTKEQIKGGTGDE KKAKEKIEKKGEKKEKKQQS IAGSADSKPIDVSRLD
Post Translational Modifications Cleaved by caspase-7 in response to apoptosis to produce EMAP-II.
Function Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7.
Protein Name Aminoacyl Trna Synthase Complex-Interacting Multifunctional Protein 1
Multisynthase Complex Auxiliary Component P43 Cleaved Into - Endothelial Monocyte-Activating Polypeptide 2
Emap-2
Endothelial Monocyte-Activating Polypeptide Ii
Emap-Ii
Small Inducible Cytokine Subfamily E Member 1
Database Links Reactome: R-HSA-2408522
Reactome: R-HSA-379716
Cellular Localisation Nucleus
Cytoplasm
Cytosol
Secreted
Endoplasmic Reticulum
Golgi Apparatus
Enriched In Secretory Vesicles Of Pancreatic Alpha Cells And Secreted From The Pancreas In Response To Low Glucose Levels
Secreted In Response To Hypoxia
Also Secreted In Response To Both Apoptotic And Necrotic Cell Death
Alternative Antibody Names Anti-Aminoacyl Trna Synthase Complex-Interacting Multifunctional Protein 1 antibody
Anti-Multisynthase Complex Auxiliary Component P43 Cleaved Into - Endothelial Monocyte-Activating Polypeptide 2 antibody
Anti-Emap-2 antibody
Anti-Endothelial Monocyte-Activating Polypeptide Ii antibody
Anti-Emap-Ii antibody
Anti-Small Inducible Cytokine Subfamily E Member 1 antibody
Anti-AIMP1 antibody
Anti-EMAP2 antibody
Anti-SCYE1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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