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  • 产品名称：Human Interleukin-24 protein (Recombinant) (STJP000601)

  • 产品型号：STJP000601
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human Interleukin-24 protein (Recombinant) (STJP000601)
详情介绍：
Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human Interleukin-24-protein was developed from hek293. For use in research applications.
Conjugation: Unconjugated
Formulation: Lyophilised from 0.2 Mu m filtered solution in PBS, pH.4 including% (w/v) trehalose.
Dilution Range: Spin the vial and reconstite in distilled water to a concentration not less than 0.1 mg/mL. This can then be diluted into other buffers.
Storage Instruction: Can be stored in working aliquots at°C-°C C for one month, or at-20°C C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. NA
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than.1 ng/µg (1EU/µg). NA
Immunoreactivity: Activity was determined by the ability to inhibit growth of human A549 cancer cells at concentrations ranging between-100 ng/ml. NA
Gene Symbol: IL24
Gene ID: 11009
Uniprot ID: IL24_HUMAN
Immunogen Region: Mature chain
Immunogen: Optimized DNA sequence encoding Human Interleukin-24 mature chain including a C-terminal His tag was expressed in HEK293 cells. NA
Immunogen Sequence: MNFQQRLQSL WTLARPFCPP LLATASQMQM VVLPCLGFTL LLWSQVSGAQ GQEFHFGPCQ VKGVVPQKLW EAFWAVKDTM QAQDNITSAR LLQQEVLQNV SDAESCYLVH TLLEFYLKTV FKNYHNRTVE VRTLKSFSTL ANNFVLIVSQ LQPSQENEMF SIRDSAHRRF LLFRRAFKQL DVEAALTKAL GEVDILLTWM QKFYKL NA
Tissue Specificity Up-regulated in melanoma cells induced to terminally differentiate.
Post Translational Modifications Glycosylated. Ubiquitination at Lys-122 promotes proteasomal degradation.
Function Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis. Possesses antiviral functions and induces the type I intereferon response during influenza infection. Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1. In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1. Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal. In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2.
Protein Name Interleukin-24
Il-24
Melanoma Differentiation-Associated Gene 7 Protein
Mda-7
Suppression Of Tumorigenicity 16 Protein
Database Links Reactome: R-HSA-8854691
Cellular Localisation Secreted
Alternative Protein Names Interleukin-24 protein
Il-24 protein
Melanoma Differentiation-Associated Gene 7 Protein protein
Mda-7 protein
Suppression Of Tumorigenicity 16 Protein protein
IL24 protein
MDA7 protein
ST16 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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