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  • 产品名称：Human Interleukin-3 protein (Recombinant) (STJP000228)

  • 产品型号：STJP000228
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human Interleukin-3 protein (Recombinant) (STJP000228)
详情介绍：
Host: CHO cells
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human Interleukin-3-protein was developed from cho cells. For use in research applications.
Conjugation: Unconjugated
Formulation: Lyophilised from 0.2 Mu m filtered PBS solution pH7.0.
Dilution Range: Spin the vial and reconstite in distilled water to a concentration not less than 0.1 mg/mL. This can then be diluted into other buffers.
Storage Instruction: Can be stored in working aliquots at°C-°C C for one month, or at-20°C C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. NA
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than.1 ng/µg (1EU/µg). NA
Immunoreactivity: The ED (50) was determined by the the ability to induce IFNg production in NK cells was foundless than0.1 ng/ml. NA
Gene Symbol: IL3
Gene ID: 3562
Uniprot ID: IL3_HUMAN
Immunogen Region: Mature chain
Immunogen: Optimized DNA sequence encoding Human Interleukin-3 mature chain was expressed in CHO cells. NA
Immunogen Sequence: MSRLPVLLLL QLLVRPGLQA PMTQTTPLKT SWVNCSNMID EIITHLKQPP LPLLDFNNLN GEDQDILMEN NLRRPNLEAF NRAVKSLQNA SAIESILKNL LPCLPLATAA PTRHPIHIKD GDWNEFRRKL TFYLKTLENA QAQQTTLSLA IF NA
Tissue Specificity Activated T-cells, mast cells, natural killer cells.
Function Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Stimulates also mature basophils, eosinophils, and monocytes to become functionally activated. In addition, plays an important role in neural cell proliferation and survival. Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation. Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB. Receptor stimulation results in the rapid activation of JAK2 kinase activity leading to STAT5-mediated transcriptional program. Alternatively, contributes to cell survival under oxidative stress in non-hematopoietic systems by activating pathways mediated by PI3K/AKT and ERK.
Protein Name Interleukin-3
Il-3
Hematopoietic Growth Factor
Mast Cell Growth Factor
Mcgf
Multipotential Colony-Stimulating Factor
P-Cell-Stimulating Factor
Database Links Reactome: R-HSA-512988
Reactome: R-HSA-5673001
Reactome: R-HSA-8939247
Reactome: R-HSA-912526
Cellular Localisation Secreted
Alternative Protein Names Interleukin-3 protein
Il-3 protein
Hematopoietic Growth Factor protein
Mast Cell Growth Factor protein
Mcgf protein
Multipotential Colony-Stimulating Factor protein
P-Cell-Stimulating Factor protein
IL3 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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