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  • 产品名称：Human Kininogen-1/KNG1 protein (Recombinant) (C-His) (STJP002685)

  • 产品型号：STJP002685
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human Kininogen-1/KNG1 protein (Recombinant) (C-His) (STJP002685)
详情介绍：
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human Kininogen-1/KNG1-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunoreactivity: Measured by its ability to inhibit papain cleavage of a fluorogenic peptide substrate Z-FR-AMC. The IC50 value approximately is 1 nM.
Gene Symbol: KNG1
Gene ID: 3827
Uniprot ID: KNG1_HUMAN
Immunogen Region: Gln 19-Ser 427
Immunogen: Recombinant Human Kininogen-1/KNG1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln 19-Ser 427) of human Kininogen-1 (Accession #NP_000884) fused with a 6×His tag at the C-terminus.
Post Translational Modifications Bradykinin: Bradykinin is inactivated by ACE, which removes the dipeptide Arg-Phe from its C-terminus. Bradykinin is released from kininogen by plasma kallikrein. Hydroxylation of Pro-383 occurs prior to the release of bradykinin. Phosphorylated by FAM20C in the extracellular medium. N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. (Microbial infection) Bradykinin is generated upon proteolytic cleavage by S.pyogenes SpeB to produce hypotension during septic shock.
Function Kininogens are inhibitors of thiol proteases. HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII.HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes. LMW-kininogen inhibits the aggregation of thrombocytes. LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting. Bradykinin: The active peptide bradykinin is a potent vasodilatator that is released from HMW-kininogen shows a variety of physiological effects: (A) influence in smooth muscle contraction, (B) induction of hypotension, (C) natriuresis and diuresis, (D) decrease in blood glucose level, (E) it is a mediator of inflammation and causes (E1) increase in vascular permeability, (E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action).
Protein Name Kininogen-1
Alpha-2-Thiol Proteinase Inhibitor
Fitzgerald Factor
High Molecular Weight Kininogen
Hmwk
Williams-Fitzgerald-Flaujeac Factor Cleaved Into - Kininogen-1 Heavy Chain - T-Kinin
Ile-Ser-Bradykinin - Bradykinin
Kallidin I - Lysyl-Bradykinin
Kallidin Ii - Kininogen-1 Light Chain - Low Molecular Weight Growth-Promoting Factor
Database Links Reactome: R-HSA-114608
Reactome: R-HSA-140837
Reactome: R-HSA-375276
Reactome: R-HSA-381426
Reactome: R-HSA-416476
Reactome: R-HSA-418594
Reactome: R-HSA-8957275
Cellular Localisation Secreted
Extracellular Space
Alternative Protein Names Kininogen-1 protein
Alpha-2-Thiol Proteinase Inhibitor protein
Fitzgerald Factor protein
High Molecular Weight Kininogen protein
Hmwk protein
Williams-Fitzgerald-Flaujeac Factor Cleaved Into - Kininogen-1 Heavy Chain - T-Kinin protein
Ile-Ser-Bradykinin - Bradykinin protein
Kallidin I - Lysyl-Bradykinin protein
Kallidin Ii - Kininogen-1 Light Chain - Low Molecular Weight Growth-Promoting Factor protein
KNG1 protein
BDK protein
KNG protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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