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  • 产品名称：JAK3 Blocking Peptide peptide (Phospho) (STJ505419)

  • 产品型号：STJ505419-250
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
JAK3 Blocking Peptide peptide (Phospho) (STJ505419)
详情介绍：
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Phospho-JAK3 Blocking Peptide is synthetically produced from the 750-800 sequence and is suitable for use in western blot applications.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: JAK3
Gene ID: 3718
Uniprot ID: JAK3_HUMAN
Immunogen Region: 750-800
Immunogen: Synthetic peptide taken within amino acid region 750-800 on human JAK3 protein. Phosphorylated tyrosine 785 residue.
Tissue Specificity In NK cells and an NK-like cell line but not in resting T-cells or in other tissues. The S-form is more commonly seen in hematopoietic lines, whereas the B-form is detected in cells both of hematopoietic and epithelial origins.
Post Translational Modifications Tyrosine phosphorylated in response to IL-2 and IL-4. Dephosphorylation of Tyr-980 and Tyr-981 by PTPN2 negatively regulates cytokine-mediated signaling (Probable).
Function Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A and STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.
Peptide Name Tyrosine-Protein Kinase Jak3
Janus Kinase 3
Jak-3
Leukocyte Janus Kinase
L-Jak
Database Links Reactome: R-HSA-1266695
Reactome: R-HSA-201556
Reactome: R-HSA-5673001
Reactome: R-HSA-6785807
Reactome: R-HSA-8854691
Reactome: R-HSA-8983432
Reactome: R-HSA-8985947
Reactome: R-HSA-9020558
Reactome: R-HSA-9020958
Reactome: R-HSA-912526
Reactome: R-HSA-9679191
Cellular Localisation Endomembrane System
Peripheral Membrane Protein
Cytoplasm
Alternative Peptide Names Tyrosine-Protein Kinase Jak3 protein
Janus Kinase 3 protein
Jak-3 protein
Leukocyte Janus Kinase protein
L-Jak protein
JAK3 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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